Twin Column Technology

YMC offers chromatography systems designed to run batch and continuous (twin-column) processes. The proven ability to scale up from the benchtop Contichrom CUBE to the production scale Contichrom TWIN means YMC is with you every step of the way.

Contichrom® CUBE Benchtop System

The Contichrom CUBE is a flexible purification system for process development of (bio-)pharmaceuticals such as monoclonal antibodies, peptides, and oligonucleotides.  It enables single-column batch and twin-column counter-current processes such as capture (CaptureSMB®) for monoclonal antibody (mAb) affinity chromatography and MCSGP for peptides.


  • Performs batch, integrated batch, and continuous processes
  • Pump flow rates of up to 36 mL/min or 100 mL/min
  • Equipped with ChromIQ automation software
  • Scales up to the YMC Contichrom TWIN

For more detailed information, view the product page or download our brochure.


Contichrom® TWIN Process Scale Systems

YMC’s Contichrom TWIN Platform consists of feature-rich, GMP-ready skids for LPLC and HPLC. Built on our patented twin-column approach to continuous purification, these systems are proven to significantly increase productivity. The Contichrom TWIN can also be run in single-column batch mode, allowing users to save space and capital equipment costs by purchasing one system that can operate in multiple modes.

Contichrom TWIN HPLC

  • Features patented MCSGP technology for enhanced yield and purity
  • Simple, two-column design runs both batch and continuous processes
  • Equipped with industry-leading high-pressure pumps
  • Ideal for applications such as synthetic peptides, oligonucleotides, and ADCs
  • Scale up from the Contichrom CUBE benchtop instrument

Contichrom TWIN LPLC

  • Features patented CaptureSMB® technology for significantly faster processing speeds
  • Simple, two-column design runs both batch and continuous processes
  • Employs industry-leading pumps with digital pump control technology
  • Ideal for capture steps using Protein A or IEX separations for most protein purifications
  • Scales up from the Contichrom CUBE

Find more information in the links below or reach out to