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Achieve superior biomolecule purification with U.S. supplied YMC Dynamic Axial Compression (DAC) Columns. We now offer ASME U-Stamped DAC Columns—assembled and certified in the United States.

This presentation explores the evolution of peptide purification, from the early days of reversed-phase HPLC to today’s large-scale manufacturing challenges. It covers practical strategies for preparative method development, stationary phase selection, and efficient scale-up, illustrated by a case study on tirzepatide purification. The session also introduces continuous chromatography using MCSGP technology and highlights its potential for process intensification in modern peptide manufacturing.

YMC America will be the First U.S.-Based Supplier of ASME U-Stamped DAC Columns. The company’s DAC columns support pharmaceutical and biopharmaceutical customers from process development through commercial production. Systems are used in laboratory, pilot, and production-scale chromatography applications, including purification processes for peptides, oligonucleotides, and small-molecule APIs.

Therapeutic peptides are an emerging class of active pharmaceutical ingredients that, together with other classes of bioproducts, have been attracting considerable attention due to their unique advantages. Their structure is based on well-defined amino acid sequences that may or may not contain structural modifications, resulting in molecules that generally range from 500 to 5000 Da. Currently, many examples can be used as medicines related to hormones, growth factors, neurotransmitters, among others.

Purifying Antisense Oligonucleotides (ASOs) via traditional single-column batch chromatography often leaves downstream teams facing a frustrating trade-off: sacrifice valuable target product in impure side-fractions, or settle for lower overall purity.