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Contichrom TWIN HPLC

YMC Contichrom® TWIN HPLC

Featuring patented MCSGP technology for enhanced yield and purity

The YMC Contichrom® TWIN HPLC system is designed around our two-column continuous process principle. This technology accelerates validation, simplifies maintenance, reduces costly down-time, and minimizes operating expenses.

In addition to the feature-rich standardized platform, YMC can provide customized solutions to address your specific needs. We employ a team of seasoned engineers, fabricators, and technicians to design and build every system – all under one roof.

What is MCSGP?

MCSGP (Multi-column Counter-current Solvent Gradient Purification) is a two-column process in which side fractions that contain impure product are internally (automatically) recycled in a periodic closed-loop process while pure product is continuously extracted. This eliminates the need for repeated chromatography and the associated time and resources for sampling and testing.

The result?

  • Little product is lost
  • Pure product yield is maximized without any accumulation of impurities
  • Target purity is retained
MCSGP Schematic vs Batch

Contichrom TWIN HPLC Benefits and Specifications

  • Industry-leading high-pressure pumps
  • Panel design allows for use in hazardous locations
  • Wide range of pressure and flow rates
  • Improved yield by up to 30-60%
  • Reduced solvent consumption
  • Significant increase in productivity
  • Considerable savings in the collection, storage, analysis, and blending or reprocessing of side fractions

YMC also offers the following options to enhance the system:

  • Additional inlet and outlet (fraction) valves
  • Filters
  • Pre-Column analytics
  • Hazardous location design
  • Sampling valves
  • Automation through customer-selected integrator (YMC would assist in developing a functional specification.)

Additional customizations available upon request.

Industry-Leading High-Pressure Pumps

The Contichrom TWIN HPLC is manufactured using Industry-leading high-pressure pumps that deliver maximum durability, flow accuracy, and precision throughout a wide gradient range.

Maximum operating pressure: 80 bar
Ambient temperature range: 4 – 25 °C
Process temperature range: 4 – 65 °C

System (HPLC) Flow rate range*
Column ID range
Contichrom TWIN 100 .01 .67 5 10
Contichrom TWIN 300 .03 3.33 10 20
Contichrom TWIN 500 .13 8.33 20 45
Contichrom TWIN 1000 .29 16.67 30 60
* recommended system flow rate range for MCSGP applications

Quality and Regulatory Considerations

As with all Contichrom platform equipment, the Contichrom TWIN HPLC system is built to meet high quality expectations. The design and construction of the equipment meet the following standards, assuring a safe, ergonomic system capable of performing within the guidelines of the FDA:

  • System designed for GMP operation and validation
  • Enables 21 CFR part 11 compliance
  • USP Class VI materials and seals
  • Digitally controlled metering pumps
  • Operation in Class I Div. II / ATEX

Interested in Learning More?

For more information about this or our other chromatography systems, contact us or visit one of these related pages:

Contichrom TWIN HPLC

Custom multi-column / continuous chromatography system for HPLC

YMC Single Column LPLC

Custom single-column / batch chromatography system for LPLC

YMC Single Column HPLC

Custom single-column / batch chromatography system for HPLC

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