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Reversed Phase Overview

Products for Reversed Phase Separation

YMC offers many products for reversed phase chromatography. To find the right product for your method, scroll through the comparison tables below or use the links to the left to jump to the desired category.

For more specific information, including applications and purchase options, click the product name below.

Hybrid Silica Particle

Product Name Phase USP Pore Size (Å) Particle Size (µm) Carbon Content (%) pH Range Bonding Endcapping Typical Applications
C18 L1 120 1.9, 3, 5 20 1 – 12 trifunctional multi-stage acidic, neutral, basic compounds, medium polar compounds, peptides, oligonucleotides, small molecules, amino acids, APIs, sugars
C18 L1 120 7, 10, 15, 20 20 2 – 10 trifunctional multi-stage acidic, neutral, basic compounds, peptides, oligonucleotides, small molecules, amino acids, APIs, sugars
C18 L1 80 1.9, 3, 5 25 1 – 12 trifunctional multi-stage stereoisomers and hydrophobic analytes, fatty acids
C8 L7 120 1.9, 3, 5 17 1 – 12 trifunctional multi-stage acidic, neutral, basic compounds
YMC-Triart Prep C8-S C8 L7 120 10, 15, 20 17 2 – 10 trifunctional multi-stage acidic, neutral, basic compounds, peptides, oligonucleotides, small molecules, amino acids, APIs
YMC-Triart Prep Bio200 C8 C8 L7 200 10 14 2 – 10 trifunctional multi-stage peptides (especially insulin, insulin-like peptides), oligonucleotides, proteins
C4 L26 300 1.9, 3, 5 1 – 10 trifunctional multi-stage peptides, proteins, antibodies
C18 L1 300 1.9, 3, 5 1 – 12 trifunctional multi-stage acidic, neutral, basic compounds
pentafluorophenyl L43 120 1.9, 3, 5 15 1 – 8 trifunctional none aromatic stereoisomers, halogenated and polar compounds
phenylbutyl L11 120 1.9, 3, 5 17 1 – 10 trifunctional multi-stage aromatic compounds, pharmaceuticals, sweeteners
phenylbutyl L11 120 10 17 2 – 10 trifunctional multi-stage acidic, neutral, basic compounds, peptides, small proteins, phenols, aromatics
YMC-Triart Prep C4-S C4 L26 120 10 14 2 – 10 trifunctional multi-stage non-polar peptides

100% aqueous stable (no phase de-wetting for reversed phase)
Larger particle sizes available for direct scale-up

C18 Products

Product Name Phase USP Pore Size (Å) Particle Size (µm) Carbon Content (%) pH Range Bonding Endcapping Typical Applications
C18 L1 120 1.9, 3, 5 20 1 – 12 trifunctional multi-stage acidic, neutral, basic compounds, medium polar compounds, peptides, oligonucleotides, small molecules, amino acids, APIs, sugars
YMC-Triart C18 ExRS C18 L1 80 1.9, 3, 5 25 1 – 12 trifunctional multi-stage stereoisomers and hydrophobic analytes, fatty acids
C18 L1 300 1.9, 3, 5 1 – 12 trifunctional multi-stage acidic, neutral, basic compounds
C18 L1 120 7, 10, 15, 20 20 2 – 10 trifunctional multi-stage acidic, neutral, basic compounds, peptides, oligonucleotides, small molecules, amino acids, APIs, sugars
Hydrosphere C18 C18 L1 120 2, 3, 5 12 2 – 8 Monomeric Yes Strong polar compounds, water-soluble vitamins
J’Sphere ODS-H80 C18 L1 80 4 22 1 – 9 Polymeric Yes positional isomers, complexing agents
J’Sphere ODS-L80 C18 L1 80 4 9 2 – 7.5 Polymeric Yes positional isomers, complexing agents
J’Sphere ODS-M80 C18 L1 80 4 14 2 – 7.5 Monomeric Yes positional isomers, complexing agents
Meteoric Core C18 C18 L1 80 2.7 7 1.5 – 10 trifunctional Yes fast analysis of basic and coordinating compounds
Meteoric Core C18 BIO C18 L1 160 2.7 5 1.5 – 10 trifunctional Yes fast analyses of peptides and small proteins, ideal for peptide mapping
YMC-Pack ODS-A C18 L1 120, 200, 300 3, 5 17, 12, 7 2 – 7.5 Monomeric Yes validated API methods
YMC-Pack ODS-A-HG C18 L1 120, 200, 300 10, 15, 20, 50 17, 12, 7 2 – 7.5 validated API methods
YMC-Pack ODS-AL C18 L1 120 5 17 2 – 7.5 Monomeric No tocopherols, fat-soluble vitamins, disinfectants
YMC-Pack ODS-AM C18 L1 120 3, 5 17 2 – 7.5 Monomeric Yes purines, phenols, alkaloids
YMC-Pack ODS-AQ C18 L1 120, 200 3, 5 14, 10 2 – 7.5 Monomeric Yes strong polar compounds
YMC-Pack ODS-AQ-HG C18 L1 120, 200 10, 15, 20, 50 14, 10 2 – 7.5 strong polar compounds
YMC-Pack Pro C18 C18 L1 120 2, 3, 5, 10 16 2 – 8 Monomeric Yes Antioxidants, metabolites, APIs
YMC-Pack Pro C18 RS C18 L1 80 3, 5 22 1 – 10 Polymeric Yes Stereoisomers and hydrophobic analytes

100% aqueous stable (no phase de-wetting for reversed phase)
Larger particle sizes available for direct scale-up

C8 Products

Product Name Phase USP Pore Size (Å) Particle Size (µm) Carbon Content (%) pH Range Bonding Endcapping Typical Applications
C8 L7 120 1.9, 3, 5 17 1 – 12 trifunctional multi-stage acidic, neutral, basic compounds
YMC-Triart Prep C8-S C8 L7 120 10, 15, 20 17 2 – 10 trifunctional multi-stage acidic, neutral, basic compounds, peptides, oligonucleotides, small molecules, amino acids, APIs
YMC-Triart Prep Bio200 C8 C8 L7 200 10 14 2 – 10 trifunctional multi-stage peptides (especially insulin, insulin-like peptides), oligonucleotides, proteins
YMCbasic C8 L7 200 3, 5, 10, 15, 20 7 2 – 7.5 Monomeric Yes basic molecules, anilines, alkaloids, antidepressants
Meteoric Core C8 C8 L7 80 2.7 5 1.5 – 9 trifunctional Yes n-terminal sequencing
YMC-Pack C8 C8 L7 120, 200, 300 3, 5 10, 7, 4 2 – 7.5 Monomeric Yes proteins and peptides, estrogens
YMC-Pack C8-HG C8 L7 120, 200, 300 10, 15, 20, 50 10, 7, 4 2 – 7.5 Monomeric Yes proteins and peptides, estrogens
YMC-Pack Pro C8 C8 L7 120 3, 5 10 2 – 7.5 Monomeric Yes Acidic, neutral, basic and chelating compounds, drugs/ metabolites

Larger particle sizes available for direct scale-up

C4 Products

Product Name Phase USP Pore Size (Å) Particle Size (µm) Carbon Content (%) pH Range Bonding Endcapping Typical Applications
C4 L26 300 1.9, 3, 5 1 – 10 trifunctional multi-stage peptides, proteins, antibodies
YMC-Triart Prep C4-S C4 L26 120 10 14 2 – 10 trifunctional multi-stage non-polar peptides
YMC-Pack C4 C4 L26 120, 200, 300 3, 5 7, 5, 3 2 – 7.5 Monomeric Yes biological separations, polar compounds
YMC-Pack C4-HG C4 L26 120, 200, 300 10, 15, 20, 50 7, 5, 3 2 – 7.5 Monomeric Yes biological separations, polar compounds
YMC-Pack Pro C4 C4 L26 120 3, 5 7 2 – 7.5 Monomeric Yes Polar acidic, neutral, basic and chelating compounds

100% aqueous stable (no phase de-wetting for reversed phase)

Coreshell

Product Name Phase USP Pore Size (Å) Particle Size (µm) Carbon Content (%) pH Range Bonding Endcapping Typical Applications
Meteoric Core C18 C18 L1 80 2.7 7 1.5 – 10 trifunctional Yes fast analysis of basic and coordinating compounds
Meteoric Core C18 BIO C18 L1 160 2.7 5 1.5 – 10 trifunctional Yes fast analyses of peptides and small proteins, ideal for peptide mapping and
Meteoric Core C8 C8 L7 80 2.7 5 1.5 – 9 trifunctional Yes n-terminal sequencing

Phenyl Phases

Product Name Phase USP Pore Size (Å) Particle Size (µm) Carbon Content (%) pH Range Bonding Endcapping Typical Applications
phenylbutyl L11 120 1.9, 3, 5 17 1 – 10 trifunctional multi-stage aromatic compounds, pharmaceuticals, sweeteners
pentafluorophenyl L43 120 1.9, 3, 5 15 1 – 8 trifunctional none aromatic stereoisomers, halogenated and polar compounds
phenylbutyl L11 120 10 17 2 – 10 trifunctional multi-stage acidic, neutral, basic compounds, peptides, small proteins, phenols, aromatics
YMC-Pack Ph Phenyl L11 120 3, 5 9 2 – 7.5 Monomeric Yes aromatic compounds, phenols, fullerenes, sweeteners
YMC-Pack Ph-HG Phenyl L11 120, 200, 300 10, 15, 20, 50 9 2 – 7.5 Monomeric Yes aromatic compounds, phenols, fullerenes, sweeteners

100% aqueous stable (no phase de-wetting for reversed phase)
Larger particle sizes available for direct scale-up

Specialty Phases

Product Name Phase USP Pore Size (Å) Particle Size (µm) Carbon Content (%) pH Range Bonding Endcapping Typical Applications
YMC Carotenoid C30 L62 proprietary 3, 5 proprietary 2 – 7.5 Polymeric Yes isomeric carotenes, retinols, steroids, fat-soluble vitamins
YMC-Pack CN Cyano L10 120, 300 3, 5 7, 3 2 – 7.5 Monomeric Yes steroids, catechols
YMC-Pack CN-HG Cyano L10 120, 200, 300 10, 15, 20, 50 7, 3 2 – 7.5 Monomeric Yes steroids, catechols
YMC-Pack TMS C1 L13 120 3, 5 4 2 – 7.5 Monomeric Yes water-soluble vitamins
YMC-Pack TMS-HG C1 L13 120, 200, 300 10, 15, 20, 50 4 2 – 7.5 Monomeric Yes water-soluble vitamins
YMC PAH proprietary L118 proprietary 3, 5 proprietary 2 – 6.5 none PAHs, PCBs

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