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Contichrom TWIN LPLC

YMC Contichrom® TWIN LPLC

Featuring CaptureSMB® technology for faster capture of Protein A

Our multi-column chromatography systems offer significant advantages to those who need to increase capacity (de-bottleneck downstream) or reduce Protein A cost. Take advantage of the most simple GMP scale multi-column technology with YMC’s Contichrom TWIN “2C-PCC” solution.

When compared to conventional batch processes, the system delivers enhanced resin capacity utilization, decreased buffer consumption, and increased product concentration.

Simple, elegant, and includes:

  • Pump(s) with a hygienic design capable of delivering industry best-in-class precise flow
  • Multiple inlet and outlet valves
  • Air sensors to protect the columns or prevent dry running conditions
  • pH, conductivity, pressure, and temperature probes/sensors
  • Coreolis flow meters to control and/or verify pump flow rates
  • Dual wavelength UV monitors in the range of 280 and 300 nm
  • All necessary tubing, valves, instruments, connections, and safety devices for GMP process requirements
  • System automation and control with an easy-to-follow user interface

What is CaptureSMB® Technology?

Unlike batch chromatography, which uses only 50-60% of resin material, the CaptureSMB process fully loads one column and captures product breakthrough on a second interconnected column. This ensures maximum product capture and efficient utilization of all available affinity resin.

The technology offers two-fold faster processing times and up to 50% savings in Protein A resin and buffer.

CaptureSMB Process

Process Intensification and Flexibility on a Single Skid

YMC’s Contichrom TWIN maximizes asset utilization and saves space and cost using pre-packed or conventional columns with the option to have multiple modes of operation on a single skid.

  • Multi-column continuous or extended batch operation
  • Conventional batch
  • Buffer in-line dilution capability integrated
  • Sequential polishing (two different steps, e.g., bind/elute – flow-through) with no holdup

Key Advantages

Proven Scale-Up / Scale-Down:

GMP customers have proven the direct scale-up/scale-down between our Contichrom CUBE benchtop instrument and the Contichrom TWIN LPLC.

Intuitive Software for Twin-Column Operation

The Contichrom TWIN LPLC automation and control software is designed to be user-friendly. Operators can easily navigate and manage process setup, execution, and reporting. The software is designed to enable 21 CFR Part 11 compliance.

Advanced Pumps and Fluidics

The Contichrom TWIN LPLC system uses industry-leading LEWA ecodos pumps and is enhanced with an exclusive digital pump control technology. This provides wide flow-range accuracy for improved product yield and purity as well as industry-leading precision and batch-to-batch reproducibility.

Designed With Minimal Holdup Volumes

The use of optimal piping, component arrangements, and sizing produces symmetric flow paths between the two columns.

Interested in Learning More?

For more information about this or our other chromatography systems, contact us or visit one of these related pages:

YMC Single Column LPLC

Custom single-column / batch chromatography system for LPLC

YMC Single Column HPLC

Custom single-column / batch chromatography system for HPLC

Contichrom TWIN HPLC

Custom multi-column / continuous chromatography system for HPLC

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