Skip to main content

Monoclonal Antibodies (mAbs)

At YMC, we provide many choices for mAb-related separations. Some examples:

  • Triart Bio C4 is used for reversed phase separations of intact mAbs and other large proteins.
  • YMC BioPro HIC BF is a new phase ideal for separation of antibody drug conjugates by hydrophobic interaction (HIC).
  • YMC BioPro Ion Exchange columns are useful for mAb charge variant analysis.

Of course, these columns are not restricted to these applications; and these applications are not restricted to these columns… and we’d be happy to help you sort out the best choice for your specific application(s).

However … the topic of this entry is “none of the above.” Instead, let’s spend a minute or two on Size Exclusion Chromatography (SEC) for mAbs.

YMC’s newest size exclusion column uses a stationary phase specifically designed for separating monoclonal antibodies. The product, YMC-SEC MAB, utilizes a 3µm, 250Å dihydroxypropyl stationary phase bonded to a silica gel base.

The 250Å pore size of YMC-SEC MAB is well-suited for separating aggregates from monomer and is also effective at resolving lower molecular weight fragments. YMC-SEC MAB delivers high resolution and excellent peak shape over a broad range of molecular weights (10kDa to 700kDa).

YMC-SEC MAB has been shown to work well for both characterization and quality control of antibody drugs.

Benefits of YMC-SEC MAB

  • Excellent lot-to-lot reproducibility
  • Exceptional resolution
  • Designed for antibody sizing separations

More information is just a click away: https://www.ymcamerica.com/ymc-sec-mab/

Also contact: info@ymcamerica.com; call 888-341-8380.

 

Posted on July 19, 2019.

Related Posts

Multicolumn Countercurrent Solvent Gradient Purification Process To Be Discussed By YMC at the World Biopharma Forum 2022

March 23, 2022

Multicolumn Countercurrent Solvent Gradient Purification Process To Be Discussed By YMC at the World Biopharma Forum 2022

History shows that uptake of innovation is metered in the biopharma industry, but if the invention has checked all the “user need” boxes, its acceptance has an inflection point. This inflection point, when graphed, resembles a hockey stick (hopefully pointing
YMC’s BioPro is a Reliable Tool for Analyzing PEGylated Proteins

January 15, 2022

YMC’s BioPro is a Reliable Tool for Analyzing PEGylated Proteins

Ligand® Pharmaceuticals Inc. had an excellent success utilizing YMC’s BioProIEX to analyze PEGylated protein charge variants reproducibly. They developed a characterization method for PEGylated biotherapeutic proteins that can provide increased information without compromising peak shape and resolution and wanted to
We’re Making Moves To Serve You Better

July 12, 2021

We’re Making Moves To Serve You Better

YMC America just completed the combination and expansion of our US operations at our YMC campus in Devens, MA. This puts our columns and stationary phase team under the same roof (actually, several roofs) with the research, design, and manufacturing

Designed and developed by