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Dynamic Axial Compression Columns (DACs)

YMC provides dynamic axial compression columns suited for laboratory, pilot, and industrial scale. These automated self-packing columns allow for an easy, cost-effective refill of packing material that results in a column bed yielding superior durability and reproducibility. Our DAD series operates using a downward-driving piston that maintains constant pressure on the bed during use and also simplifies packing and unpacking.

Highlights

  • ASME U‑Stamped DAC Columns (inner diameter 300-1000)
  • Cost-effectiveness increased with self-packing
  • Superior column performance, durability, and reproducibility provided by constant pressurization (Axial Compression Technology)
  • Optional slurry container permits hygienic automated packing procedures
  • Simple and safe operation
  • Compatible with IQ/OQ and explosion-proof operation

YMC America designs its DAC columns in accordance with ASME Section VIII, Division 1 and manufactures them under an active ASME Certificate of Authorization (U‑Stamp and R‑Stamp). Columns (inner diameter 300-1000) are assembled, inspected, pressure‑tested, and U‑stamped at our Devens, Massachusetts facility in the United States under YMC’s ASME‑approved quality control program, with full U‑1A documentation and National Board registration. While key components are sourced globally, all ASME‑required pressure‑boundary fabrication, inspection, and certification are performed in our United States facility. This makes YMC America the only provider offering US-stamped DAC columns built for the demands of peptide, oligonucleotide, and small‑molecule API production.

DAD Series

Overview

DAD Diagram

Column Performance

This data shows repacking data obtained by using a 50 mm ID DAC column.

After repacking the column seven times, “plates/m” and “Tf” values are still as good as in the initial state.

DAC Performance

Seamless Scale-up

The chromatography on the right hand side shows a scale-up example from an analytical 4.6 mm I.D. column to a 50 mm I.D. DAC column.

This indicates that the very similar separation pattern of analytical scale is also reproducible at the preparative scale.

Seamless Scale-up

Specifications

All columns are 700 mm in length with a 100 – 400 mm bed length

Model Number Maximum Pressure (MPa) Inner Diameter (mm) Slurry Container Model Number2 Detailed Specs Sheet
DAD-50 10 50 SC-2-20 DAD50
DAD-100 10 100 SC-10-20SA DAD100
DAD-150 10 150 SC-22-20 DAD150
DAD-200 10 200 SC-30-20 DAD200
DAD-300 10 300 SC-80-45 DAD300
DAD-4501 71 450 SC-140-45 DAD450
DAD-600 7 600 SC-300-135 DAD600
DAD-800 7 800 Inquire DAD800
DAD-1000 5 1000 Inquire DAD1000
1 DAD-450 with pressure limit 10 MPa is also available.
2 Slurry containers are optional.
Only YMC America offers DAC columns (inner diameter sizes 300-1000) that are U.S. -assembled, U.S. inspected, and U-stamped under an active ASME Certificate of Authorization.

Request a Quote

For more information or to request a quote, reach out to your local YMC rep or fill out our contact form.

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