Fundamental to the biopharmaceutical industry, the manufacture of therapeutic monoclonal antibodies (mAbs) has steadily advanced since their introduction into the market in 1986. As proteins with a highly defined structure produced from modified mammalian cells, mAbs can be engineered to have uniquely impactful therapeutic effects.
As demand for mABs has grown, so have calls for cost reduction. YMC has responded to this need by offering unique and innovative twin-column (continuous) technology that not only reduces the cost of mAbs, but also lowers the environmental impact and increases productivity.
YMC offers an array of ways to enhance mAb-related separations.
YMC-Pac Diol 2um
YMC BioPro HIC BF
YMC BioPro HIC HT
Enrichment of a product-related compounds by N-Rich
BioPro IEX Columns
YMC Biochromatography Columns Catalogue
YMC multi-column technologies
Comparison of Multicolumn Capture Processes
YMC Contichrom® TWIN CaptureSMB® LPLC
YMC EcoPrime Twin LPLC Platform – FAQ’s
UC-based dynamic process control of twin-column LPLC system
Design and operation of a continuous integrated monoclonal antibody production process
CaptureSMB for the continuous purification of mAbs with high productivity and load
Experimental design of a twin-column countercurrent gradient purification process
An Evaluation of YMC’s Strong Cation-Exchange Stationary Phase for the Analysis of Charged Isoforms of a Commercially Available Antibody Drug
Effect of Particle Size, Pore Size and Column Configuration for the Analysis of Antibody Aggregates by SEC
Use of Small Particle YMC SEC and IEX Materials for Improved Characterization of Monoclonal Antibodies
Development of a High Resolution SEC Column Suited for Analysis of Monoclonal Antibody Aggregates and Fragments
Investigation of Pore Size, Particle Size, and Column Geometry Effects on SEC Analysis of Monoclonal Antibodies
Downstream process development of monoclonal antibodies in high-yield and high-purity by affinity and ion-exchange chromatography 2019
Lab to GMP scale continuous chromatography
Continuous capture chromatography as part of an integrated downstream purification platform for mAbs
Capture SMB; Twin-column chromatography – how it works, economics, and applications
Scale-Up of Twin-Column Periodic Counter-Current Chromatography for MAb Purification
Contichrom in Blood Plasma Fractionation
BioPro Smart Sep Ion Exchange
Downstream process development of monoclonal antibodies in high-yield and high-purity by affinity and ion-exchange chromatography
mAb isoform profile tuning obtaining a biobetter productbiobetter productusing the Contichrom CUBE FPLC Systemwith high productivity and load
Increasing Capacity Utilization in Protein A Chromatography
Use of New YMC-Triart 1.9μm UHPLC Stationary Phase for Fast Peptide Mapping of Monoclonal Antibodies
Mini Webinar Library on mABs and rProteins by YMC TWIN Column CaptureSMB
Webinar: Sequential (orthogonal) polishing chromatography; a “pool-less” process and how it works
TWIN 500 LPLC Tour
Case studies – customer data from CaptureSMB experiences of twin-column system
Use our extensive Applications Search page to mine a dynamically growing collection of over 350 YMC-produced application notes.
The data can be searched by any combination of several variables, including sample classification, compound name (including partial names), and column parameters.
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