YMC-Triart Diol-HILIC
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High-Performance Columns for Polar Compound Separations
Hydrophilic Interaction Liquid Chromatography (HILIC) is a powerful separation mode specifically designed for polar organic compounds that show poor retention in reversed-phase systems.
In conventional reversed-phase HPLC, highly polar compounds often elute near the solvent front or co-elute with matrix components, resulting in poor resolution and ion suppression during MS detection.
HILIC solves this challenge by using a polar stationary phase and a mobile phase rich in organic solvent (typically acetonitrile). A thin, water-enriched layer forms on the silica surface, promoting partitioning and hydrogen-bond interactions that enhance the retention and selectivity of polar analytes.
YMC’s HILIC columns provide exceptional reproducibility, mechanical stability, and compatibility with LC-MS, UHPLC, and high-throughput workflows, which make them ideal for pharmaceuticals, metabolites, and bioanalytical compounds.
Characteristics
- Superior chemical durability
- Ideal for the separation of polar and hydrophilic compounds that are not retained by reversed phase chromatography
- Can be used for LC/MS
Applications
Typical applications include: amino acids, water soluble vitamins, sugars, antibodies, proteins, peptides
Specifications
| Stationary Phase | dihydroxypropyl (USP L20) |
|---|---|
| Bonding | Trifunctional |
| Endcapping | None |
| Mode | HILIC |
| Particle Size | 1.9, 3, 5 µm |
| Pore Size | 120 Å |
| Carbon Content | 12% |
| pH Range | 2 – 10 |
| Temperature Upper Limit | 50 °C |
| Temperature Recommended Range | 20 – 40 °C |
Available Formats
UHPLC Resin (1.9 µm)
- Prepacked columns & guards
- Capillary (< 1 mm ID)
- Analytical (1.0 – 8.0 mm ID)
- Biocompatible options (2.1 & 4.6 mm ID)
Analytical Resin (3 – 5 µm)
- Prepacked columns & guards
- Capillary (< 1 mm ID)
- Analytical (1.0 – 8.0 mm ID)
- Biocompatible & high-pressure options (2 – 4.6 mm ID)
- Preparative (10 mm ID & above)
- Bulk resin
