YMC offers a wide array of chromatography products specifically designed for biomolecule separations, including ion-exchange (IEX), size exclusion (SEC), hydrophobic interaction (HIC), and reversed-phase (RP) columns and resins. This lineup includes wide-pore materials (200Å, 250Å, and 300Å) for large proteins and peptides, as well as 120Å and 160Å products for smaller molecular weight applications such as peptide mapping. In addition, almost all of YMC’s biomolecule stationary phases are directly scalable to larger particle sizes for preparative purification/production applications, from lab to pilot scale.
BioPro IEX QF/SF and QA/SP are ion-exchange columns based on porous hydrophilic polymer beads (methacrylate) with low nonspecific adsorption of proteins. BioPro resins exhibit superior resolution, high binding capacity, and high recovery for various biomolecules, and allow highly efficient and effective analysis and laboratory-scale purification of biopharmaceutical proteins such as antibodies.
YMC BioPro HIC HT is a hydrophobic interaction chromatography (HIC) resin utilizing a butyl (C4) stationary phase bonded to non-porous hydrophilic polymer (methacrylate) particles. This HIC phase is specifically designed for fast, high resolution separations of proteins and biopharmaceutical drugs such as monoclonal antibodies (mAbs), including drug-to-antibody ratio (DAR) analysis of antibody drug conjugates (ADCs).
For more information on BioPro IEX columns, click the appropriate button below.
QA/SP Porous BioPro IEX
For more information on YMC BioPro HIC HT columns, click the button below.
YMC-Pack Diol-SEC are size exclusion chromatography columns utilizing a dihydroxypropyl stationary phase bonded to silica gel. Diol-120, 200, and 300 are suitable for molecular weight determination of proteins with molecular weights of 10,000 to several hundred thousand Daltons. Diol-60 is most suitable for the separation of peptides or oligosaccharides whose molecular weights are 10,000 Da or less.
YMC-SEC MAB is a silica-based size exclusion chromatography column utilizing a dihydroxypropyl stationary phase bonded to 3µm silica, specifically designed for antibody separations. The 250Å pore size makes it an excellent choice for not only resolving aggregates from monomer, but also for effectively resolving lower molecular weight fragments as well. YMC-SEC MAB exhibits excellent resolution and peak shape over a wide molecular weight range of 10kDa to 700kDa.
For more information on YMC-Pack Diol-SEC columns, click the appropriate button below.
For more information on YMC-SEC MAB columns, click the button below.
YMC offers three main products for reversed-phase biomolecule separations:
For more information on a specific reversed-phase product,
click the appropriate button below.
Columns, Guards and Accessories are only available for purchase online in North America or through our distributors.
To purchase consumables outside North America, please find your local distributor.
For YMC systems’ sales outside of North America and Europe, find your regional office contact information here.