Chiral Columns and Accessories - CHIRAL ART
High-Performance Columns for Reliable Enantiomeric Resolution
Chiral chromatography is a specialized technique used to separate enantiomers; i.e., mirror-image molecules that cannot be superimposed. These compounds often exhibit different biological activities, toxicities, or pharmacological effects, making accurate separation essential in pharmaceutical, biotechnology, and fine chemical applications.
YMC’s CHIRAL ART series features polysaccharide-derived chiral stationary phases (CSPs) based on amylose and cellulose tris-carbamate derivatives, available in both coated and immobilized formats. These columns provide exceptional stereoselectivity, durability, and solvent versatility, supporting normal-phase, reversed-phase, and supercritical fluid chromatography (SFC) modes.
From analytical screening to preparative-scale purification, CHIRAL ART columns deliver consistent, reproducible performance backed by YMC’s decades of chromatographic expertise.
Immobilized Type
CHIRAL ART Immobilized Polysaccharide Derivatives Series
Highlights:
- Unique immobilized chiral selector
- Wide range of usable solvents provides added flexibility
- Can be used for SFC or LC (reversed phase, normal phase, polar organic)
- Usable pH range: 2.0 – 9.0
- Temperature range: 0 – 40° C
- Pressure limit: 30 MPa (4,350 psi)
| Product | Particle Size | CHIRAL Selector | USP Class |
|---|---|---|---|
| CHIRAL ART Amylose-SA | 3 µm, 5 µm, 10 µm, 20 µm | Amylose tris (3,5-dimethylphenylcarbamate) |
L99 |
| CHIRAL ART Cellulose-SB | 3 µm, 5 µm, 10 µm, 20 µm | Cellulose tris (3,5-dimethylphenylcarbamate) |
– |
| CHIRAL ART Cellulose-SC | 3 µm, 5 µm, 10 µm, 20 µm | Cellulose tris (3,5-dichlorophenylcarbamate) |
L119 |
| CHIRAL ART Cellulose-SJ | 3 µm, 5 µm, 10 µm, 20 µm | Cellulose tris (4-methylbenzoat) |
– |
| CHIRAL ART Cellulose-SZ | 3 µm, 5 µm | Cellulose tris (3-chloro-4-methylphenylcarbamate) |
– |
Coated Type
CHIRAL ART Coated Polysaccharide Derivatives Series
Highlights:
- Polysaccharide chiral selectors
- Wide application range
- Can be used for SFC or LC (reversed phase, normal phase, polar organic)
- Temperature range: 0 – 40° C
- Pressure limit: 30 MPa (4,350 psi)
| Product | Particle Size | CHIRAL Selector | USP Class |
|---|---|---|---|
| CHIRAL ART Amylose-C Neo | 3 µm, 5 µm, 10 µm, 20 µm | Amylose tris (3,5-dimethylphenylcarbamate) |
L51 |
| CHIRAL ART Cellulose-C | 3 µm, 5 µm, 10 µm, 20 µm | Cellulose tris (3,5-dimethylphenylcarbamate) |
L40 |
LC Columns & Accessories
| Product | Phase / Type | Separation Mode(s) | Pore Sizes | Particle Sizes | pH Range | Available Formats | Link to Order |
|---|---|---|---|---|---|---|---|
| CHIRAL ART Amylose-C Neo | Polysaccharide derivatives | Chiral | Proprietary | 3 µm5 µm | - | Analytical (1 - 8 mm ID)Preparative (10 mm ID & above) | |
| CHIRAL ART Amylose-SA | Polysaccharide derivatives | Chiral | Proprietary | 3 µm5 µm10 µm20 µm | 2 - 9 | Analytical (1 - 8 mm ID)Preparative (10 mm ID & above) | |
| CHIRAL ART Cellulose-C | Polysaccharide derivatives | Chiral | Proprietary | 3 µm5 µm10 µm20 µm | - | Analytical (1 - 8 mm ID)Preparative (10 mm ID & above) | |
| CHIRAL ART Cellulose-SB | Polysaccharide derivatives | Chiral | Proprietary | 3 µm5 µm10 µm20 µm | 2 - 9 | Analytical (1 - 8 mm ID)Preparative (10 mm ID & above) | |
| CHIRAL ART Cellulose-SC | Polysaccharide derivatives | Chiral | Proprietary | 3 µm5 µm10 µm20 µm | 2 - 9 | Analytical (1 - 8 mm ID)Preparative (10 mm ID & above) | |
| CHIRAL ART Cellulose-SJ | Polysaccharide derivatives | Chiral | Proprietary | 3 µm5 µm10 µm | 2 - 9 | Analytical (1 - 8 mm ID)Preparative (10 mm ID & above) | |
| CHIRAL ART Cellulose-SZ | Polysaccharide derivatives | Chiral | Proprietary | 3 µm5 µm | 2 - 9 | Analytical (1 - 8 mm ID)Preparative (10 mm ID & above) |
Coated vs. Immobilized CHIRAL ART Columns
Coated CHIRAL ART Columns
- Feature a polysaccharide-based chiral selector physically coated onto the silica surface
- Offer maximum selectivity for many enantiomeric separations
- Are recommended for use with traditional solvents that are gentle on the coating (e.g., hexane/alcohol mixtures)
- Are ideal for routine analytical and screening applications where the highest chiral recognition is desired
Immobilized CHIRAL ART Columns
- Utilize a chemically bonded chiral selector for enhanced solvent and mechanical stability
- Provide broader solvent compatibility, including polar and aqueous phases
- Are suitable for method development, reversed-phase, or SFC workflows, and for scale-up to preparative purification
- Allow for greater flexibility in method optimization and robustness in demanding conditions
When to Use Chiral Chromatography
Chiral separation is ideal when:
- You need to distinguish or quantify enantiomers or diastereomers with high accuracy
- One enantiomer exhibits different biological or pharmacological activity than the other
- You require regulatory compliance in determining optical purity of APIs or intermediates
- You are developing or scaling methods from research to process-scale purification
Why Choose YMC CHIRAL ART?
Exceptional Reproducibility
Every CHIRAL ART column is precision-engineered and batch-tested to ensure reliable, lot-to-lot performance and consistent retention characteristics.
Method Flexibility
Choose coated or immobilized CHIRAL ART columns to match your workflow, and supporting a wide range of solvents and mobile phase systems (pH 2–9) across normal-phase, reversed-phase, and SFC modes.
Scalability from Lab to Production
YMC provides CHIRAL ART media in multiple particle sizes (3 µm, 5 µm, 10 µm, 20 µm) and column formats, allowing smooth scale-up from analytical to preparative purification.
Solvent Compatibility and Durability
Immobilized CHIRAL ART columns withstand aggressive solvents that coated columns cannot tolerate. They are ideal for challenging separations and flexible method development.
Application-Specific Support
Our technical experts can help you select the right CSP chemistry for your compound class, whether it’s amino acids, β-blockers, oligonucleotides, or natural products.
Chiral Chromatography FAQs
Q: What types of chiral stationary phases does YMC offer?
YMC CHIRAL ART columns include amylose and cellulose tris-carbamate derivatives in both coated and immobilized formats, providing broad selectivity for diverse chiral compounds.
Q: Can CHIRAL ART columns be used with reversed-phase or SFC systems?
Yes. Immobilized CHIRAL ART columns are compatible with normal-phase, reversed-phase, and SFC separations, allowing flexible method development and MS detection.
Q: What particle sizes and formats are available?
CHIRAL ART columns are available in 3 µm, 5 µm, 10 µm, and 20 µm particle sizes for analytical to preparative workflows. Bulk media options are also available for large-scale purification.
Q: How does CHIRAL ART ensure reproducibility?
Each lot is manufactured under strict quality control using high-purity silica and advanced coating or immobilization technology, ensuring consistent resolution and retention.
Need Help Choosing the Right Chiral Column?
Our team can guide you in selecting the optimal stationary phase and mobile-phase mode for your specific analyte.
YMC also offers custom packing, method development kits, and scale-up support for chiral separations from discovery to production.
Contact us today or browse our selection of columns.
