The downstream operation in biopharma production is dedicated to the precise separation and purification of target molecules (proteins) to strict regulatory standards. This process requires multiple steps involving several chromatographic and filtration devices and consumables. YMC has advanced the conventional unit processes through innovation that begins at the lab scale and extends through GMP scale production of these large molecule therapeutics. Continuous chromatography is only one of our disruptive technologies leading the industry to more cost-effective and efficient ways to produce these life-saving drugs.
We work with clients that are the leading producers of:
At every turn, we aim to make things easy for you:
YMC is steeped in industry best practices and routinely develops new designs, solutions, and equipment to advance processing and control trends such as batch processing and the move from batch to continuous processes. Our Contichrom TWIN LPLC is an industry-first innovation, leading the evolution to continuous capture chromatography (and so much more).
We understand the sensitive nature of proteins and use thoughtful engineering design and pumps known for GMP compliance and low shear design. We know how to integrate multi-unit/multi-process solutions for maximum throughput and operational ease. (Integrating buffer in-line dilution right into a chromatography system is a YMC innovation that saves significant space and cost.)
Often, a single system of our design has the capacity range of multiple competitive units, delivering the footprint savings that manufacturing managers crave.
We know your molecule is unique. Where we shine is when we work together to customize a system to your needs, so you get exactly what you want. We’re friendly and flexible—small enough to listen but big enough to deliver innovation.
Our innovation in digital control of the industry-leading metering pump and user-adaptable control systems provides ultimate control and yield during the purification of valuable bioproducts. Our proprietary design methods commonly deliver accuracy previously only attainable in analytical instruments. With gradient accuracy well below +/-0.5%, YMC Process Technologies has been making enormous strides in the hardware and now enhances our offering with systems with columns, methods development, and resins from YMC.
We draw from YMC’s nearly 40-year history in supplying critical separations and purification technologies to the world’s largest firms. YMC never leaves you with supplier “finger-pointing” frustrations.
YMC gives our customers a full range of tools and services to draw from, including:
We welcome the chance to lower your total cost of ownership (TCO), speed your time-to-market, reduce your line’s footprint, and improve product consistency and integrity of your biopharmaceutical processes. And with a global network of specialists from Singapore to Tokyo, Zurich to Dublin, and Boston to San Diego, you’re always close to a local YMC contact.
YMC-BioPro Preparative Screening Kits
MSDS and Product Care
BioPro IEX Columns
YMC-Triart Bio C4
YMC BioPro MiniChrom Columns
YMC Biochromatography Columns Catalogue
YMC EcoPrime Twin LPLC Platform – FAQ’s
YMC multi-column technologies
Use of New YMC-Triart 1.9μm UHPLC Stationary Phase for Fast Peptide Mapping of Monoclonal Antibodies
Purifying Common Light-Chain Bispecific Antibodies
mAb isoform profile tuning obtaining a biobetter productbiobetter productusing the Contichrom CUBE FPLC Systemwith high productivity and load
A newly developed hydrophilic polymer-based ion exchange chromatography media and purification of immunoglobulin Y from egg yolk
A newly developed hydrophilic polymer-based ion exchange resin for analysis and purification of various biological molecules
Developments of Hydrophilic Polymer-based Ion Exchange Media for Analysis and Purification of Various Biological Molecules
Hybrid Approach to Continuous Downstream Biomanufacturing
Process characterization and validation for continuous chromatography systems
CaptureSMB for the continuous purification of mAbs with high productivity and load
Modified Cohn Process using CaptureSMB and MCSGP to optimize yield and purity for high value plasma proteins
Downstream process development of monoclonal antibodies in high-yield and high-purity by affinity and ion-exchange chromatography 2019
Lab to GMP scale continuous chromatography
Continuous capture chromatography as part of an integrated downstream purification platform for mAbs
Capture SMB; Twin-column chromatography – how it works, economics, and applications
UC-based dynamic process control of twin-column LPLC system
Purification of Anti-Body Conjugates using the Contichrom CUBE FPLC System
Mini Webinar Library on mABs and rProteins by YMC TWIN Column CaptureSMB
Case studies – customer data from CaptureSMB experiences of twin-column system
Webinar: Sequential (orthogonal) polishing chromatography; a "pool-less" process and how it works
Twin Modeling Tool v8.7 YPT EcoPrime.xlsm
A Swiss Army Knife for Modern Biomanufacturing
Report and Recipe tools for twin-column chromatography / LPLC’s
Use our extensive Applications Search page to mine a dynamically growing collection of over 350 YMC-produced application notes.
The data can be searched by any combination of several variables, including sample classification, compound name (including partial names), and column parameters.
ACCESS APPLICATIONS SEARCH
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Columns, Guards and Accessories are only available for purchase online in North America or through our distributors.
To purchase consumables outside North America, please find your local distributor.
For YMC systems’ sales outside of North America and Europe, find your regional office contact information here.