Interest in the analysis and purification of cannabis-related molecules continues to grow:
Cannabinoids in general exhibit poor water solubility. Separation of cannabinoids is, therefore, well suited to reversed-phase chromatography. Conveniently, compounds that may also be of related interest, such as formulation products, excipients, and APIs, are typically also best suited to reversed-phase separation.
For example, cannabidiol (CBD) is under investigation for several indications, including pain relief and sleeplessness. Most CBD formulators are interested in supplying pure CBD, with tetrahydrocannabinol (THC) and other cannabinoids removed.
YMC purification technology, such as Multicolumn Countercurrent Solvent Gradient Purification (MCSGP), is capable of isolating target compounds with high purity, yield, and throughput, significantly outperforming single-column chromatography. See our Application Note for details.
In the analytical lab, YMC technology provides a number of reliable HPLC/UHPLC stationary phases for high-resolution separation of cannabinoids, including THC, CBD, cannabinol (CBN), cannabigerol (CBG), cannabidiolic acid (CBDA), and tetrahydrocannabinolic acid (THCA).
YMC-Triart C18 and YMC Meteoric Core C18 (core-shell stationary phase) are two high-performance choices that deliver efficient separations, high resolution of adjoining peaks, fast separations, excellent reproducibility, and long column life. YMC-Triart C18 is an excellent choice for laboratory investigations of methods that will be scaled up to process-level purification because of the scalability of the behavior of the phase itself.
YMC-Triart C18 for Preparative Purification of Cannabidiol from a Commercially Available Hemp Oil Extract
YMC – What We Do
Highly pure Cannabidiol (CBD) by twin-column chromatography (MCSGP)
HPLC Separation of Cannabidiol and Melatonin on YMC-Triart C18 – Application Note
Preparative Purification of CBD from Hemp Oil – Application Note
YMC Insight Center – A Virtual Tour
Use our extensive Applications Search page to mine a dynamically growing collection of over 350 YMC-produced application notes.
The data can be searched by any combination of several variables, including sample classification, compound name (including partial names), and column parameters.
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