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YMC America will make a donation to St Jude Children’s Hospital for every prepacked column sold.

Can be used in both normal phase and reversed phase modes.

YMC-Pack CN can be used for both normal phase and reversed phase analyses due to the medium polarity of the cyanopropyl phase bonded to the silica base particle. It can be used in normal phase with low-polarity mobile phases such as hexane, or in reversed phase with highly-polar mobile phases such as methanol and water. YMC-Pack CN can be useful for shortening analysis time in situations where retention is substantial using C18 or C8, or when separation optimization is difficult.

In reversed phase mode, cyano columns are the most polar and least retentive of all reversed phase packings. Extremely hydrophobic compounds which do not elute in standard C18 and C8 packings can be retained using typical reversed phase eluents. In addition, the unique nitrile chemistry provides different selectivity from both phenyl and standard aliphatic (C18, C8, and C4) reversed phase packings. Large pore size 300Å packing materials are also available for the analysis of biomolecules in order to utilize this unique selectivity.

In normal phase mode, cyano is a bonded phase that can be used as an alternative to silica. Bonded normal phase columns have the advantage of faster equilibration and more uniform surface activity compared to bare silica gel.

*Tip: To extend column lifetime, continued switching back and forth 
between normal and reversed phase solvents should be avoided.


  • Stable, high coverage, monomerically-bonded phase
  • Can be used in reversed phase and normal phase
  • Fully endcapped
  • Alternative selectivity
  • Available in 300 Å for biomolecule analysis
  • Useful for SFC applications


Typical applications include:
steroids, catechols


Stationary Phase cyano
(USP L10)
Bonding Monomeric
Particle Size 3, 5, 10, 
15, 20, 50 µm
Pore Size 120, 200, 300 Å
Carbon Content 7%, 3%
pH Range 2 – 7.5
Temperature Upper Limit 50 °C
Temperature Recommended Range 20 – 40 °C

*not all combinations of particle & pore size are available

Preparative Particle Sizes

YMC-Pack CN with particle sizes of 10 µm and higher are available as part of the YMC*Gel High Grade (HG) series. These resins boast improved mechanical stability as well as narrower particle size and pore size distribution. YMC-Pack CN-HG can be purchased in prepacked analytical and preparative columns or in bulk resin format.

Available Formats

  • Prepacked columns & guards
    • Capillary (< 1 mm ID)
    • Analytical (1.0 – 8.0 mm ID)
    • Preparative (10 mm ID & above)
  • Bulk resin

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