This is our flagship Chromatography system. It offers unique capabilities for mastering complex separation challenges by using our proprietary processes. The user-friendly software automates the use of these processes:
Resolution: Analytical resolution at preparative scale
MCSGP, being the only scalable ternary chromatographic process solution, offers large economic benefits compared to batch processes, which have an intrinsic weakness of having to choose between yield and purity. With MCSGP processes, both yield and purity are always superior compared to an analogous batch process and, in addition, productivity is increased up to tenfold while buffer/solvent consumption is reduced by 70%. MCSGP processes can be run with smaller equipment footprints, offering large CAPEX and OPEX savings. A single polish step of a biopharmaceutical product employing MCSGP could save up to 4 mio USD p.a.
N-Rich® enables the enrichment of a minor compound while simultaneously depleting the large excess of interfering components. It is particularly useful for the isolation of product-related impurities and saves tedious repetitive analytical separations to isolate the compound of interest. With N-Rich®, this can be achieved in a short time without repetitive manual handling.
ChromIQ is the operating software of the Contichrom preparative chromatography equipment. The software is designed to allow the users to operate the equipment without expert knowledge of the underlying processes. This is done through an interface where the process input templates are filled out by the operator, showing immediately the process output data. In this way, the right process can be designed before running it.
The software uses wizard modules supporting different processes and process control functions, depending on the Contichrom product. The wizards are pre-programmed software modules for easy operation. Following ChromIQ, software wizards are included in the different Contichrom products:
The wizards also help to convert the conventional batch process to the more efficient twin-column countercurrent processes.
Dynamic process control tools like AutomAb and MControl keep CaptureSMB and MCSGP processes at an optimal set point during steady-state operation.
ChromIQ also has an expert operating mode for deeper control and autonomous expert programming. This function is deactivated by default and can be activated.
The software contains all essential elements for 21CFR part 11 compliance:
We offer and recommend useful accessories to our Contichrom systems, helping to facilitate chromatographic operations:
Contichrom CUBE bench top instrument
The N-Rich Process Principle
Contichrom CUBE FAQ’s
FDA selects twin-column chromatography system by YMC ChromaCon for evaluation
Purification of Anti-Body Conjugates using the Contichrom CUBE FPLC System
mAb isoform profile tuning obtaining a biobetter productbiobetter productusing the Contichrom CUBE FPLC Systemwith high productivity and load
N-Rich – Automated enrichment and purification of minor compounds from complex matrices
N-Rich: A tool for efficient isolation of minor compounds from complex matrices
N-Rich Impurity Insight Service
TIDES Presentation: Purification of Peptides by Twin-column Countercurrent Chromatography
Enrichment of a product-related compounds by N-Rich
CaptureSMB for the continuous purification of mAbs with high productivity and load
AutomAb®: UV-based Dynamic Process Control for CaptureSMB
Purification of a GalNAc-cluster-conjugated oligonucleotide by reversed-phase twin-column continuous chromatography
Virus Clearance Validation across Continuous Capture Chromatography
Continued insights into virus clearance validation across continuous capture chromatography, Journal of Chromatography A
Model assisted process characterization and validation for a continuous two column protein A capture process
Highly pure Cannabidiol (CBD) by twin-column chromatography (MCSGP)
Optimal model-based design of the twin-column CaptureSMB process improves capacity utilization and productivity in protein A affinity capture
Increasing Capacity Utilization in Protein A Chromatography
Twin-Column Cation-Exchange Chromatography for the Purification of Biomolecules
Comparison of batch and continuous multi-column protein A capture processes by optimal design
Model-assisted process characterization and validation for a continuous two-column protein A capture process
Scale-Up of Twin-Column Periodic Counter-Current Chromatography for MAb Purification
Design and operation of a continuous integrated monoclonal antibody production process
Process Intensification for the Purification of Peptidomimetics: The Case of Icatibant through Multi-column Countercurrent Solvent Gradient Purification (MCSGP)
Novel benchtop FLPC ChromIQ software (Contichrom CUBE unit)
CUBE Basics: A next gen chromatography tool
Contichrom CUBE bench-top FPLC – a chromatographic new tool for drug discovery and purification
N-Rich® – Automated process of enriching of side fraction / impurity for QC
Virus clearance and carryover study on twin-column (continuous chromatography) system
UV-based dynamic process control of twin-column HPLC system (AutoPeak)
Use our extensive Applications Search page to mine a dynamically growing collection of over 350 YMC-produced application notes.
The data can be searched by any combination of several variables, including sample classification, compound name (including partial names), and column parameters.
ACCESS APPLICATION SEARCH
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