LPLC Chromatography Systems (GMP)

Custom or standard. Conventional or continuous LPLC.

LPLC (low-pressure liquid chromatography) LPLC is the cornerstone to production of therapeutics in the biopharmaceutical industry.

YMC LPLCs are able to be employed in the capture step (e.g., Protein A) as well as polishing steps (e.g., AEX/CEX). LPLC enables the purification of drugs from oligonucleotides to larger molecules such as monoclonal antibodies (mAbs) and vaccines.

For decades, YMC has designed, engineered, automated, manufactured, and serviced LPLC systems from 0.1 mL/min to over 60 LPM capacity for many of the world’s leading biopharmas. These systems can be supplied as conventional single-column batch skids or as YMC’s leading twin-column continuous systems. YMC supplies standard platforms and works with customers who need custom designs.

Our systems are fabricated to ASME/ BPE standards and comply with most regional standards (e.g., UL, CE, CSA, etc.). Our control systems are PLC-based and enable use in GMP environments using our in-house software or as custom systems adaptable to third-party software (e.g., Emerson DeltaV). Full customer-guided FAT services in our manufacturing facility and on-site support are available.

Choose batch or continuous chromatography—or both

Our advanced solutions—standard or customized to the needs of our customers—leverage a long history of fluid engineering and intellectual property. You’re assured of both accuracy and footprint savings.

YMC platform products and customized solutions provide you with:

  • Analytical performance at pilot and process scale
  • Single skid systems that offer the flow range (capacity) of two (2) competitive systems
  • Unmatched accuracy and reproducibility
  • Flexibility in your processing/automation control with customer-adaptable PLC-based software and DeltaV options
  • Unique On-board Buffer In-line Dilution (BID) options
  • Reduced footprint by up to 66%
  • Contichrom TWIN LPLC—twin-column chromatography system for batch and continuous process using YMC’s patented CaptureSMB and AutomAb Dynamic Control Technology in GMP environments. Read more about our Contichrom TWIN technology here.

To complement our systems, we offer resins and/or columns for a variety of LPLC applications, including:

  • Affinity Chromatography
  • Ion Exchange Chromatography
  • Mixed/Multimodal Chromatography
  • Hydrophobic Interaction Chromatography (HIC)
  • Size exclusion, including gel filtration
  • Reversed-Phase (RP) Chromatography

Need HPLC? We also offer standard cost-efficient systems or custom high-performance liquid chromatography (HPLC) systems

Modeling Tool for Continuous Chromatography Systems

Download this flexible tool to see how you can save time and money with continuous bio-processing.


More Resources Related to This Topic

Application Information


Application Search

Use our extensive Applications Search page to mine a dynamically growing collection of over 350 YMC-produced application notes.

The data can be searched by any combination of several variables, including sample classification, compound name (including partial names), and column parameters.

Contact YMC America

For more information on products and services from YMC, YMC ChromaCon, or just to say hello, get in touch with us by clicking on the button below.