UV-based dynamic process control of twin-column LPLC system (AutomAb)

This 20 minute (+Q&A) presentation deals with the dynamic UV-based control of twin-column capture (CaptureSMB) or “AutomAb”. Robust operation in clinical and commercial manufacturing, continuous processes benefit greatly from dynamic process monitoring. For the capture process, the “AutomAb” control accounts for changes in resin capacity, titer and adjusts the operating parameters such that load and yield are kept constantly at the set point.

Such controls are among the essential tools to ensure robust long-term operation over multiple cycles. This presentation elucidates the working principles of this patented dynamic process control method and provides a case study for capture application.