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YMC-Pack Diol-NP

A normal phase alternative to silica.

YMC-Pack Diol-NP is a versatile alternative to silica for normal phase separations and provides much better reproducibility when compared to bare silica material. It shows typical normal phase retention behavior when used with low-polarity mobile phases due to hydroxyl groups on the surface of the stationary phase acting as polar groups.

Hydrogen bonding with the Diol-NP layer is not as strong as with silanols on a bare silica surface. As a result, the bonded layer’s hydroxyl groups provide good selectivity without excessive retention. YMC-Pack Diol-NP can also be used in HILIC-mode with organic/water mobile phases.


  • Improved peak shape versus bare silica
  • Good selectivity without excessive retention
  • High product recovery
  • Excellent bonded-phase reproducibility
  • Long column lifetime
  • High loading with prep material


Typical applications include: pharmaceutical products, metabolites, phospholipid classes


Stationary Phase dihydroxypropyl
(USP L20)
Bonding Monomeric
Particle Size 5, 10, 
15, 20, 50 µm
Pore Size 60, 120, 200, 300 Å
pH Range 2 – 7.5
Temperature Upper Limit 50 °C
Temperature Recommended Range 20 – 40 °C

*not all combinations of particle & pore size are available

Preparative Particle Sizes

YMC-Pack Diol-NP with particle sizes of 10 µm and higher are available as part of the YMC*Gel High Grade (HG) series. These resins boast improved mechanical stability as well as narrower particle size and pore size distribution. YMC-Pack Diol-NP-HG can be purchased in prepacked analytical and preparative columns or in bulk resin format.

Available Formats

  • Prepacked columns & guards
    • Capillary (< 1 mm ID)
    • Analytical (1.0 – 8.0 mm ID)
    • Preparative (10 mm ID & above)
  • Bulk resin

LC Columns & Accessories

ProductPhase / TypeSeparation Mode(s)Pore SizesParticle SizespH RangeAvailable FormatsLink to Order
YMC-Pack Diol-NPDihydroxypropylNormal Phase120 Å300 Å60 Å3 µm5 µm15 µm20 µm50 µm2 - 7.5Analytical (1 - 8 mm ID)Capillary (< 1 mm ID)Preparative (10 mm ID & above)

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