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YMC-Pack Pro C4

Excellent peak shape for basic compounds.

YMC-Pack Pro C4 columns are made using advanced endcapping technology to reduce residual silanol activity. This results in excellent peak shapes for basic compounds. In addition, the ultra pure silica and very low residual silanol activity means that these columns frequently do not require the use of ion-pairing reagents or ion-suppression techniques, making them ideal for LC/MS applications. Surface hydrophobicity is lower than that of ODS, making Pro C4 useful for fast analysis of compounds of greatly differing hydrophobic properties. Pro C4 can also be useful for separation of hydrophilic and planar compounds in cases where resolution is hard to achieve on ODS materials.


  • Superior separation of basic compounds
  • Excellent reproducibility
  • Utilizes highly pure silica gel base


Typical applications include: polar acidic, neutral, basic and chelating compounds


Stationary Phase C4 (USP L26)
Bonding Monomeric
Particle Size 3, 5 µm
Pore Size 120 Å
Carbon Content 7%
pH Range 2 – 7.5
Temperature Upper Limit 50 °C
Temperature Recommended Range 20 – 40 °C

Available Formats

  • Prepacked columns & guards
    • Capillary (< 1 mm ID)
    • Analytical (1.0 – 8.0 mm ID)
    • Preparative (10 mm ID & above)

LC Columns & Accessories

ProductPhase / TypeSeparation Mode(s)Pore SizesParticle SizespH RangeAvailable FormatsLink to Order
YMC-Pack Pro C4C4Reversed Phase120 Å3 µm5 µm2 - 7.5Analytical (1 - 8 mm ID)Capillary (< 1 mm ID)Preparative (10 mm ID & above)

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