Separate Mixed-Polarity Samples Quickly
YMC-Pack C4 (Butyl) columns are less hydrophobic than C8 or C18 packings, and generally utilize more aqueous eluents than either of these reversed-phase column types. When compared to C8 and C18 columns (using the same eluents), C4 stationary phases show significantly shorter retention for non-polar compounds. Retention of polar compounds, however, is not significantly affected. Therefore, mixtures with a wide range of component polarity are best analyzed by YMC-Pack C4. This is due to the C4 bonded phase exhibiting shorter analysis time while still maintaining high resolution when compared to longer-chain bonded chemistries.