Ultra-pure Silica-based C18
The YMC Pro Family is based on a silica with an extremely low metal content. Low metal content suppresses polar interactions, as metal impurities cause silanol groups to become more acidic. This ensures YMC Pro Family phases provide excellent resolution for a wide range of compounds, especially basic pharmaceuticals. To minimize the unwanted interactions between residual silanols and the sample molecules that are responsible for asymmetric peaks, YMC utilizes a proprietary, highly effective endcapping process. Important for every chromatographer: YMC ensures that the physical properties, such as particle size, pore size, and metal content, are extremely reproducible from lot to lot.
The combination of ultra pure silica and unique selectivity leads to a stationary phase that fulfills the relevant requirements of HPLC users. Minimal metal content and very low concentrations of residual silanols make this an ideal phase for the analysis of basic pharmaceuticals and chelating compounds, even under LC-MS conditions (ex. separation in non-phosphate buffered systems.) In addition, the possibility to separate polar compounds under highly aqueous mobile phase conditions without loss in retention, plate counts, and peak performance greatly enhances the versatility of Hydrosphere C18. These characteristics will allow Hydrosphere C18 to be used for a wide range of applications of compounds with polar functional groups.
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