N-Rich® Technology Resources

 

Visit YMC America at one of these upcoming tradeshows to learn more about N-Rich technology and other YMC products in person!

 

TIDES USA

Booth 910
May 15 – 17, 2024
Hynes Convention Center, Boston, MA

For more information, visit the TIDES website.

 

PREP Symposium

Booth 4
May 29 – 30, 2024
Loews Hotel, Philadelphia, PA

For more information about the PREP Symposium, visit the PREP 2024 website.

 

The N-Rich process principle explained

The N-Rich technique is a twin-column cyclical enrichment process whereby a target molecule or chromatographic region is selectively enriched while the undesired products are simultaneously depleted. The technology can be run on the Contichrom® CUBE to automate the process of impurity enrichment and purification.

This short video illustrates the N-Rich process in three main stages: accumulation, depletion, and fractionated elution.

 

Common uses for the N-Rich technique

  • isolation of product-related impurities for active pharmaceutical ingredients
  • biosimilar CMC characterization
  • characterization of antibody-drug conjugate isoforms
  • identification of biomarkers and compounds in proteomics and metabolomics research
  • purification of ultra-pure compounds as reference materials
  • isolation of impurities after stability and formulation studies

 

Read on for journal articles featuring N-Rich technology or
contact us for more information!

 

Additional Resources

 

Enrichment and recovery of oligonucleotide impurities by N-Rich twin-column continuous chromatography

In this study, the N-Rich process was used for impurity isolation from a double-stranded RNA (dsRNA) therapeutic synthetic oligonucleotide (ON) produced by solid-phase synthesis.


Enrichment and purification of peptide impurities using twin-column continuous chromatography

This study demonstrates the performance of the N-Rich process for isolation of Angiotensin II peptide impurities compared with standard analytical and preparative chromatography approaches.