The N-Rich process principle explained
The N-Rich technique is a twin-column cyclical enrichment process whereby a target molecule or chromatographic region is selectively enriched while the undesired products are simultaneously depleted. The technology can be run on the Contichrom® CUBE to automate the process of impurity enrichment and purification.
This short video illustrates the N-Rich process in three main stages: accumulation, depletion, and fractionated elution.
Common uses for the N-Rich technique
Read on for journal articles featuring N-Rich technology or
contact us for more information!
Enrichment and recovery of oligonucleotide impurities by N-Rich twin-column continuous chromatography
In this study, the N-Rich process was used for impurity isolation from a double-stranded RNA (dsRNA) therapeutic synthetic oligonucleotide (ON) produced by solid-phase synthesis.
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Enrichment and purification of peptide impurities using twin-column continuous chromatography
This study demonstrates the performance of the N-Rich process for isolation of Angiotensin II peptide impurities compared with standard analytical and preparative chromatography approaches.
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