Bulk Resins

Resins (gels)

Bulk resins allow flexibility for the user to load columns of various manufacture and size with a range of stationary phases (resins). Bulk resins are particularly useful in semi-prep and preparative chromatography, which require the production of significant quantities of purified drug substances. Bulk resins are packing materials for either HPLC or LPLC chromatography columns of the scale to perform preparative (gram) scale batches of drug products. Depending on the substance to be purified, the user has qualified the resin or gel at the bench scale likely in pre-packed columns and now procures quantities of the same resin in bulk. Bulk media is packed by the user into larger-scale columns that are not available as pre-packed and/or realize a cost benefit of bulk packaging.

As a large-scale producer of resins, YMC offers such media in pre-packed columns as well as bulk quantities of packing material, allowing seamless scale-up to semi-prep and preparative applications. Below outlines some of the bulk resins offered by YMC.

Low pressure bulk resin—prep scale applications

Based on a porous, hydrophilic polymer bead, our SAX or SCX materials deliver excellent dynamic binding capacity, high recovery, and very low non-specific adsorption. YMC-BioPro Q30 and S30 and YMC-BioPro Q75 and S75 are ideal for proteins, peptides, mAb, and other biomolecule separation. WCS and WAX phases also available.

YMC-BioPro Preparative Screening Kits are easy to use and enable resin screening, purification method development, and loadability studies. These low-cost kits make it easy to test combinations of conditions and materials. YMC-BioPro materials are also available in Atoll* formats (please inquire).

For more large molecule resin information, click here.

Prep scale bulk resin—high-pressure applications

Resins/gels (packing media)

pH Stable RP Phases

The first truly preparative scale hybrid phases available in large lot sizes. Scalable to UHPLC, YMC-Triart Prep is available in five bonded chemistries (C18, C8, Phenyl, Pentafluorophenyl, HILIC, as well as bare hybrid) up to 50 micron particle size. YMC-Triart is mechanically durable (for long life), pH resilient, and base washable.

Chiral LC (NP/RP/SFC)

Preparative Scale YMC CHIRAL is suitable both for the conventional column separations and also for dynamic axial compression (DAC) columns and simulated moving bed (SMB) systems. YMC CHIRAL bulk material is available in up to several hundred kilograms with YMC’s well-known high quality, reproducibility, and technical support.

Silica-Based Phases

YMC has achieved considerable improvements in the manufacture of its classical silica base. This has given rise to an improved generation of stationary phases with superior physical attributes: YMC*Gel High Grade (HG)-series.

For more packing material (resin) information, click here.

Application Search

Use our extensive Applications Search page to mine a dynamically growing collection of over 350 YMC-produced application notes.

The data can be searched by any combination of several variables, including sample classification, compound name (including partial names), and column parameters.

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