The isolation of minor compounds of complex mixtures is a very difficult purification task, typically done by repetitive (several hundred) runs using analytical HPLC inorder to isolate mg quantities of a minor compound for further testing. The N-Rich process is an automated multistep process that is run by the Contichrom CUBE system providing mg quantities of a desired compound at high purity. The two-step enrichment and separation step yields sufficient material of high purity for structure elucidation or subsequent structural, biochemical, cell- and even animal-based assays. It is an invaluable tool for any research and development laboratory.
N-Rich is applied for:
The N-Rich process employs a cyclic step where the desired molecule is selectively enrichment and interfering substances are depleted (see animation below). After enrichment of several hundred to thousand-fold, the enriched fraction is separated automatically, using a shallow gradient.
The Contichrom CUBE is capable of executing N-Rich processes.
Enrichment of a product-related compounds by N-Rich
N-Rich – Automated enrichment and purification of minor compounds from complex matrices
The N-Rich Process Principle
N-Rich: A tool for efficient isolation of minor compounds from complex matrices
N-Rich Impurity Insight Service
Enrichment and purification of peptide impurities using twin-column continuous chromatography
N-Rich® – Automated process of enriching of side fraction / impurity for QC
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