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Twin Column Technology

YMC offers chromatography systems designed to run batch and continuous (twin-column) processes.

The proven ability to scale up from the benchtop Contichrom CUBE to the production scale Contichrom TWIN means YMC is with you every step of the way.

Twin Column Train

Contichrom® CUBE Benchtop System

The Contichrom CUBE is a flexible purification system for process development of (bio-)pharmaceuticals such as monoclonal antibodies, peptides, and oligonucleotides. It enables single-column batch and twin-column counter-current processes such as capture (CaptureSMB®) for monoclonal antibody (mAb) affinity chromatography and MCSGP for peptides.


  • Performs batch, integrated batch, and continuous processes
  • Pump flow rates of up to 36 mL/min or 100 mL/min
  • Equipped with ChromIQ automation software
  • Scales up to the YMC Contichrom TWIN

For more detailed information, view the product page or download our brochure.

Contichrom CUBE

Contichrom® TWIN Process Scale Systems

YMC’s Contichrom TWIN Platform consists of feature-rich, GMP-ready skids for LPLC and HPLC. Built on our patented twin-column approach to continuous purification, these systems are proven to significantly increase productivity.

The Contichrom TWIN can also be run in single-column batch mode, allowing users to save space and capital equipment costs by purchasing one system that can operate in multiple modes.

Contichrom TWIN HPLC

  • Features patented MCSGP technology for enhanced yield and purity
  • Simple, two-column design runs both batch and continuous processes
  • Equipped with industry-leading high-pressure pumps
  • Ideal for applications such as synthetic peptides, oligonucleotides, and ADCs
  • Scale up from the Contichrom CUBE benchtop instrument

Contichrom TWIN LPLC

  • Features patented CaptureSMB® technology for significantly faster processing speeds
  • Simple, two-column design runs both batch and continuous processes
  • Employs industry-leading pumps with digital pump control technology
  • Ideal for capture steps using Protein A or IEX separations for most protein purifications
  • Scales up from the Contichrom CUBE

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