Uncategorized Archives

August 5, 2026

Maximizing Oligonucleotide Yield Without Sacrificing Purity

Purifying Antisense Oligonucleotides (ASOs) via traditional single-column batch chromatography often leaves downstream teams facing a frustrating trade-off: sacrifice valuable target product in impure side-fractions, or settle for lower overall purity.

April 14, 2026

Novel Approach for Differentiating mRNA Fingerprints

𝗡𝗲𝘄 𝗕𝗿𝗲𝗮𝗸𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗶𝗻 𝗺𝗡𝗥𝗔 𝗙𝗶𝗻𝗴𝗲𝗿𝗽𝗿𝗶𝗻𝘁𝗶𝗻𝗴: 𝗜𝗣𝗔𝗫 𝘅 𝗜𝗣-𝗥𝗣 𝟮𝗗-𝗟𝗖 Confirming mRNA sequences quickly and reliably is no longer a bottleneck. While traditional sequencing or LC-HRMS workflows are often labor-intensive, a 𝐭𝐰𝐨-𝐝𝐢𝐦𝐞𝐧𝐬𝐢𝐨𝐧𝐚𝐥 𝐥𝐢𝐪𝐮𝐢𝐝 𝐜𝐡𝐫𝐨𝐦𝐚𝐭𝐨𝐠𝐫𝐚𝐩𝐡𝐲 (𝟐𝐃-𝐋𝐂) approach is simplifying comprehensive mRNA characterization.

March 11, 2026

We are hiring!

We are growing and we're hiring across all functions! It takes a diverse and skilled team to do what we do, from the initial engineering concept, to the final high-polish finish, to the regional sales champions, and step in between that drives us forward.

September 9, 2025

We are Attending Boulder Peptide Symposium

Starting Monday: YMC Heads to the Boulder Peptide Symposium! September 15–18 | Boulder, CO We’re eager to attend this one-of-a-kind event, the only conference solely focused on the pharmaceutical development of peptide therapeutics. We are excited for the rapid-fire, 15-minute

September 2, 2025

Continuous Chromatography Workshop – registration open!

Meet the scientist behind the solutions. J Preston, PhD, Separation Sciences Director at YMC America, leads our applications initiatives, bringing extensive expertise in method development and chromatographic optimization to our clients’ most complex analytical challenges. Coming this October: Join J

February 9, 2021

Webinar on Continuous Countercurrent Chromatography

Twin-column continuous countercurrent chromatography is an excellent technique for achieving high yield and high purity in the manufacturing scale purification of peptide and oligo therapeutics.

November 23, 2020

Thoughts for Thanksgiving

For many, the year 2020 has been a tough one. This Thanksgiving, we thought we would put products aside for a few seconds. The tradition of the Thanksgiving Season is that everyone should pause to take a moment to be

January 31, 2020

What Could Be Better Than Chicago in Early March?

Pittcon is just around the corner – March 1-5, 2020. This year, Pittcon is in Chicago, so our advice to Pittcon attendees is to stay indoors and take in the Technical Program. While you’re there, visit YMC in booth 3113.

December 4, 2019

Your Source for Glass Columns

As users of glass columns will tell you, a glass column is more than just a glass tube with fittings. Successful use of glass columns also requires versatile provisions for connecting glass sections, adjustable plungers, column jackets for heating and/or

October 28, 2019

Now Available: YMC-Triart Bio C18 Wide Pore Hybrid C18 Designed for Use with Proteins, Peptides, Oligonucleotides

Conventional C18 stationary phases are often not ideal for reversed phase separation of larger molecules such as proteins, large peptides, and oligos. This is because the pore size on the surface of the stationary phase particles is too small –

September 30, 2019

Looking to Improve Your Bioseparations Results? Start Here.

Sometimes one question can have more than one answer. Of course, if you have a question about ANY separation, you can always contact your YMC rep, or contact us at info@ymcamerica.com. And here’s another option: start at our Biomolecule Separations

September 23, 2019

NJCG 2019 Symposium

Don’t forget to come see us this week at the North Jersey Chromatography Group’s 2019 Symposium in Princeton, NJ. (Sept. 25th, noon-6pm) See the final program here: NJCG Symposium_25 Sep 2019_Final Program