FDA purchases YMC technology

This webinar will highlight how advanced ultra-high-performance liquid chromatography (UHPLC) strategies, carefully selected stationary phases, and bioinert hardware can significantly improve the analysis and purification of peptides and oligonucleotides.

Evaluating 5' capping efficiency is a critical quality attribute in therapeutic mRNA manufacturing, directly impacting translation efficiency and transcript stability. However, separating structurally similar capped, partially capped, and uncapped species differing by just a single nucleotide remains a significant chromatographic challenge.

Ensuring the quality of single guide RNA (sgRNA) is a major hurdle in CRISPR-Cas genome editing. Because these molecules are large (~100mer) and prone to complex secondary structures, separating them from nearly identical impurities requires precision. Our latest application note