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Preparative LC systems

K-Prep

Product Information

K-Prep is a preparative chromatographic system corresponding from lab scale to industrial scale. Fully automatic operation by PC is possible. Chromatographic data and instrument data can be recorded automatically.

K-Prep LAB is designed for laboratory scale purification. It is applicable to columns with inner diameter of 20 to 200 mm.

K-Prep FC is designed for industrial scale purification. It corresponds to a GMP production plant and is capable of corresponding to validation at IQ/OQ.

K-Prep EX is an explosion-proof system for GMP production plant. Fully automatic operation by PC from non-explosion-proof area is possible.

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HIGHLIGHTS

  • Easy operation.
  • Fully automated continuous operation via computer control.
  • Precise and speedy isolation by isocratic or gradient elution operation.
  • Economically efficient with recycle separation.
  • Compact.
  • Simple maintenance.
  • Easy expansion.
  • Comply with GLP/GMP validation.

USAGE

  • Separation for peptides,proteins etc.
  • Separation for intermediate of food products, pharmaceuticals and agrichemicals.
  • Separation for fermented products.

Feature

  • Fully automatic operation
  • Manual control with easy operation
  • GMP Support

Fully automatic operation

Mobile phase, pump, automatic injector, wash valve, column switch valve, recycle valve, fraction collector all operate by computer control. K-Prep software records the real-time chromatogram and pressure. Outstanding user friendliness and reliability by programmable logic controller (PLC) allows remote control over each unit of the system.

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Manual control with easy operation

By clicking an icon on the PC display, the corresponding apparatus is manually adjusted.
K-Prep is a flexible system and can be used in a variety of chromatography modes.

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GMP Support

  • FAT
  • IQ/OQ.
  • CSV

Channel Diagram


K-Prep LAB

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K-Prep FC

FC750流路図画像


K-Prep EX

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Specification


K-Prep LAB

LAB100S
LAB100G
LAB300S
LAB300G
Gradient capability
no
yes
no
yes
Flow rate range
1-100 mL/min
1-300 mL/min
Flow rate accuracy
±2% (10 mL/min and above)
±2% (30 mL/min and above)
Maximum Pressure
15 MPa
10 MPa
High pressure line
1/16″ (0.8 mmI.D.), SUS316
1/8″ (2 mmI.D.), SUS316
Suction line
1/8″ (2 mmI.D.), FEP
1/4″ (3.9 mmI.D.), FEP
Solvent channel
2ch
4ch (2 × 2ch)
2ch
4ch (2 × 2ch)
Fraction collector
5-channel switching valve method
Sample injection
automatic injector (50 mL loop)
automatic injector (100 mL loop)
Sample syringe
25 mL (reciprocating for large quantity)
Detector
UV/VIS (195-600 nm)
Control and display
laptop PC and programmable logic controller
Software operating system
Windows 7
Power supply
AC 100V 50/60 Hz
0.6 kW
1.1 kW
0.6 kW
1.1 kW

K-Prep FC

Gradient capability
no
yes
no
yes
Flow rate range
1-750 mL/min
1-1500 mL/min
Flow rate accuracy
±2% (75 mL/min and above)
±2% (150 mL/min and above)
Maximum Pressure
10 MPa
High pressure line
1/8″ (2 mmI.D.), SUS316
1/4″ (3.9 mmI.D.), SUS316
Suction line
1/4″ (3.9 mmI.D.), FEP
3/8″ (7.5 mmI.D.), FEP
Solvent channel
2ch
4ch (2 × 2ch)
2ch
4ch (2 × 2ch)
Fraction collector
5-channel switching valve method
Sample injection
sample pump(1-300 mL/min)
Detector
UV/VIS (195-600 nm)
Control and display
laptop PC (changeble FA PC) and programmable logic controler
Software operating system
Windows 7
Power supply
AC 100V 50/60 Hz
0.6 kW
1.1 kW
0.6 kW
1.1 kW

K-Prep EX

Gradient capability*
yes
yes
yes
yes
Flow rate range
30-3000 mL/min
60-6000 mL/min
125-12500 mL/min
250-25000 mL/min
Flow rate accuracy
±2% (300 mL/min and above)
±2% (600 mL/min and above)
±2% (1250 mL/min and above)
±2% (2500 mL/min and above)
Maximum Pressure
10 MPa
High pressure line
3/8″ (7.5 mmI.D.),
SUS316
3/8″ (7.5 mmI.D.),
SUS316
1/2″ (10.2 mmI.D.),
SUS316
3/4″ (16.6 mmI.D.),
SUS316
Suction line
1/2″ (10.2 mmI.D.),
SUS316
1/2″ (10.2 mmI.D.),
SUS316
3/4″ (16.6 mmI.D.),
SUS316
1″ (22.1 mmI.D.),
SUS316
Solvent channel
4ch (2 × 2ch)
Fraction collector
5-channel switching valve method
Sample injection
sample pump
(1-300 mL/min)
sample pump
(1-1000 mL/min)
sample pump
(1-1000 mL/min)
sample pump
(30-3000 mL/min)
Detector
UV/VIS (195-600 nm)
Control and display
FA PC (control at safe area) and programmable logic controler
Software operating system
Windows 7
Power supply
three-phase AC 200V 50/60 Hz
4 kW
15 kW
15 kW
23 kW

 

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