Bulk Resins/Column Packing Materials

Resins (gels)

YMC bulk resins have been used in semi prep and preparative chromatography for decades at the largest pharmaceutical and biopharmaceutical companies and CMOs. The reason is simple: YMC bulk packing materials assure the user of pure predictable scaling for any application.

Depending on the substance to be purified, the user can qualify the resin or gel at the bench scale in our pre-packed columns and be assured that the same performance will be seen from batch to batch in bulk format. Bulk media (packed by the user into larger-scale columns) generally realize a cost benefit of bulk packaging. YMC has for decades operated large-scale resin production facilities in Japan with stock and distribution in over 10 geographies.

Below are some of the bulk resins offered by YMC.

Prep scale bulk resin—low-pressure applications

Based on a porous, hydrophilic polymer bead, our SAX or SCX materials deliver excellent dynamic binding capacity, high recovery, and very low non-specific adsorption. YMC-BioPro Q30 and S30 and YMC-BioPro Q75 and S75 are ideal for proteins, peptides, mAb, and other biomolecule separation. WCS and WAX phases are also available.

YMC-BioPro Preparative Screening Kits are easy to use and enable resin screening, purification method development, and loadability studies. These low-cost kits make it easy to test combinations of conditions and materials. YMC-BioPro materials are also available in Atoll* formats. (please inquire*)

Prep scale bulk resin—high-pressure applications

pH Stable RP Phases

YMC offers the first truly preparative scale hybrid phases available in large lot sizes. Scalable to UHPLC, YMC-Triart Prep is available in five bonded chemistries (C18, C8, Phenyl, Pentafluorophenyl, HILIC, as well as bare hybrid) up to 50 micron particle size. YMC-Triart is mechanically durable (for long life), pH resilient, and base washable.

Chiral LC (NP/RP/SFC)

Preparative Scale YMC CHIRAL is suitable for both conventional column separations and dynamic axial compression (DAC) columns and simulated moving bed (SMB) systems. YMC CHIRAL bulk material is available in quantities of up to several hundred kilograms with YMC’s well-known high quality, reproducibility, and technical support.

Silica-Based Phases

YMC has continuously improved the manufacture of its classical silica base, giving rise to an improved generation of stationary phases with superior physical attributes: YMC*Gel High Grade (HG)-series.


Application Search

Use our extensive Applications Search page to mine a dynamically growing collection of over 350 YMC-produced application notes.

The data can be searched by any combination of several variables, including sample classification, compound name (including partial names), and column parameters.

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