Our multi-column chromatography systems offer significant advantages to those who need to increase capacity (de-bottleneck downstream) or reduce Protein A cost. Our Contichrom TWIN “2C-PCC” solution is built on YMC ChromaCon intelligence and patents and helps you take advantage of the most simple GMP scale multi-column technology.
When compared to conventional batch processes, the system delivers enhanced resin capacity utilization (up to 3X), decreased buffer consumption (by over 50% in many cases), and increased product concentration, all in a simple, two-column design that eases manufacturing validation and minimizes the risk of downtime while reducing operating expense.
To guarantee consistent and reproducible performance, the Contichrom TWIN LPLC system is designed with minimal holdup volumes and symmetric flow paths between the two columns, which was accomplished by optimal piping and components arrangements and sizing.
Brochure: YMC Contichrom® TWIN CaptureSMB® LPLC
AutomAb®: UV-based Dynamic Process Control for CaptureSMB
CaptureSMB for the continuous purification of mAbs with high productivity and load
Hybrid Approach to Continuous Downstream Biomanufacturing
Webinar: Multi-funtionality of Contichrom TWIN CaptureSMB LPLC multi-column system
Video: TWIN 500 LPLC Tour
Webinar: Automation of twin-column chromatography - Contichrom TWIN LPLC and HPLC
Webinar: UV-based dynamic process control of twin-column LPLC system (AutomAb)
Webinar: Sequential (orthogonal) polishing chromatography; a "pool-less" process & how it works
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