LPLC Systems Single-Column (Batch)

Custom or standard batch chromatography systems

With YMC, you leverage our 40 years of supplying separations and purification technologies to leading chromatography system users, gaining access to cutting-edge downstream process scale systems, columns, resins, and services across the globe. YMC offers both a pre-engineered, configurable platform of advanced EcoPrime LPLCs, as well as custom designs engineered in concert with your team. We are open to collaborative design built on our pioneering and proven platform designs. Analytical accuracy at pilot and production scale!

With gradient accuracy well below +/-0.5%, yield and purity are enhanced to levels previously only attainable in analytical instruments. YMC has been making enormous strides in hardware and now enhances our offering with LPLC columns, methods development, and resins from YMC.

Buffer dilution and digital control

With YPT’s exclusive on-board buffer in-line dilution (BID) option, our EcoPrime LPLC systems reduce clean room space constrictions by performing the work of multiple competitive process units using only a single YPT process unit. With BID built into the system, users can save tons of space using concentrates precisely diluted at the point of use.

Adding proprietary digital enhancements and piping refinements to our already robust fluid control technology has earned us a reputation for innovation among global leaders in biotechnology. The digitization that allows precise metering of feed and buffers has allowed YPT’s EcoPrime LPLC to enhance yield, quality, and reproducibility in chromatography steps that have not previously been available to users.

The choice is yours

We leverage a long history of fluid engineering and intellectual property in the advanced solutions we customize to the needs of our customers. We don’t sacrifice accuracy at any point in that range while delivering footprint savings.

YMC Process Technologies off-the-shelf products and customized solutions enable you with:

  • Analytical performance at pilot and process scale!
  • Single skid systems that offer the flow range (capacity) of 2 competitive systems
  • Unmatched accuracy and reproducibility
  • Flexibility in your processing/automation control – customer adaptable PLC-based software and DeltaV options
  • Unique On-board Buffer In-line Dilution options
  • Reduced footprint by up to 66%

We offer systems, resins, and columns for a variety of methods, including:

  • Affinity Chromatography
  • Ion Exchange Chromatography
  • Mixed/Multimodal Chromatography
  • Hydrophobic Interaction Chromatography
  • Size exclusion, including gel filtration
  • Reversed-Phase Chromatography
  • Custom high-performance liquid chromatography (HPLC) systems

About YMC The Leading Fine Separations Company

We have been innovators and producers of purification science methods and products since 1980. It is our mission to equip the scientists, quality leaders, and process engineers of the pharmaceutical and biopharmaceutical industries with the most advanced insights and productivity tools for the fine separations that are crucial to the creation of life-saving therapies.


At your service with our service. In the lab, in the field, or in the classroom, YMC technicians are available to assist you.

Application Search

Use our extensive Applications Search page to mine a dynamically growing collection of over 350 YMC-produced application notes.

The data can be searched by any combination of several variables, including sample classification, compound name (including partial names), and column parameters.

Contact YMC America

For more information on products and services from YMC, YMC ChromaCon, or just to say hello, get in touch with us by clicking on the button below.