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YMC-Triart Bio C4

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YMC America will make a donation to St Jude Children’s Hospital for every prepacked column sold.

Wide pore hybrid silica phase designed for biomolecule separations.

YMC-Triart Bio C4 is an organic/inorganic hybrid silica particle derivatized with C4 (L26 USP designation) based on wide-pore (300 Å) particles. This stationary phase is designed for HPLC and UHPLC separations of proteins and oligonucleotides, and is particularly useful for intact antibody analyses run at high temperatures.

YMC-Triart Bio C4 is well-suited for high-sensitivity analysis using mass spec-friendly mobile phases containing formic acid and/or TFA.


  • Good peak shapes with mobile phases suitable for LC/MS
  • 100% aqueous stable (no phase 
de-wetting for reversed phase)
  • Suitable for the separation of intact antibodies under high temperatures (up to 90°C)
  • Excellent chemical stability and mechanical durability


Typical applications include: proteins, peptides, antibodies


Stationary Phase C4 (USP L26)
Bonding Trifunctional
Endcapping Multi-stage
Mode Reversed Phase
Particle Size 1.9, 3, 5 µm
Pore Size 300 Å
pH Range 1 – 10
Temperature Upper Limit pH 1-7: 90 °C
pH 7-12: 50 °C
Temperature Recommended Range 20 – 40 °C

Available Formats

UHPLC Resin (1.9 µm)

  • Prepacked columns & guards
    • Capillary (< 1 mm ID)
    • Analytical (1.0 – 8.0 mm ID)
    • Biocompatible options (2.1 & 4.6 mm ID)

Analytical Resin (3 - 5 µm)

  • Prepacked columns & guards
    • Capillary (< 1 mm ID)
    • Analytical (1.0 – 8.0 mm ID)
    • Biocompatible & high-pressure options (2 – 4.6 mm ID)
    • Preparative (10 mm ID & above)
  • Bulk resin

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