YMC Hydrosphere C18 Analytical Guard Columns

Ultra-pure Silica-based C18

The YMC Pro Family is based on a silica with an extremely low metal content. Low metal content suppresses polar interactions, as metal impurities cause silanol groups to become more acidic. This ensures YMC Pro Family phases provide excellent resolution for a wide range of compounds, especially basic pharmaceuticals. To minimize the unwanted interactions between residual silanols and the sample molecules that are responsible for asymmetric peaks, YMC utilizes a proprietary, highly effective endcapping process. Important for every chromatographer: YMC ensures that the physical properties, such as particle size, pore size, and metal content, are extremely reproducible from lot to lot. YMC Hydrosphere C18 consists of a hydrophilic C18 surface exhibiting enhanced polar selectivity, allowing for separation of polar compounds under high aqueous mobile phase conditions without loss of retention, plate count, or peak performance. This enhanced versatility allows Hydrosphere C18 to be used in a wide range of applications for compounds with polar functional groups.


Features & Benefits – Analytical Guard Cartridges

YMC’s Guard Column Cartridge Systems for HPLC accept cartridges of 1.0, 2.1, 3.0, or 4.0mm analytical-guard-columnsinner diameters – in either 10mm or 20mm lengths. Cartridges are available with a comprehensive selection including all stationary phase chemistries offered by YMC, ensuring compatibility between the guard column and the analytical column. Assembly is tool-free, simplifying cartridge replacement.

YMC Guard Column Cartridges require the use of a holder, P/N: XPGCHP1 for 10mm length and P/N: XPGCHP2 for 20mm length.

Product List

Product List

Please select the desired particle size to view a list of products.


Particle Size Pore Size Column I.D. (mm) Column Length (mm) Part Number Guards per Pack Requires Holder Price Quantity
3 µm 120Å 2.1 10 HS12S03-01Q1GC 5 XPGCHP1 $538.00
3 µm 120Å 3.0 10 HS12S03-0103GC 5 XPGCHP1 $538.00
3 µm 120Å 4.0 10 HS12S03-0104GC 5 XPGCHP1 $538.00
3 µm 120Å 2.1 20 HS12S03-02Q1GC 5 XPGCHP2 $658.00
3 µm 120Å 3.0 20 HS12S03-0203GC 5 XPGCHP2 $658.00
3 µm 120Å 4.0 20 HS12S03-0204GC 5 XPGCHP2 $658.00


Particle Size Pore Size Column I.D. (mm) Column Length (mm) Part Number Guards per Pack Requires Holder Price Quantity
5 µm 120Å 2.1 10 HS12S05-01Q1GC 5 XPGCHP1 $538.00
5 µm 120Å 3.0 10 HS12S05-0103GC 5 XPGCHP1 $538.00
5 µm 120Å 4.0 10 HS12S05-0104GC 5 XPGCHP1 $538.00
5 µm 120Å 2.1 20 HS12S05-02Q1GC 5 XPGCHP2 $658.00
5 µm 120Å 3.0 20 HS12S05-0203GC 5 XPGCHP2 $658.00
5 µm 120Å 4.0 20 HS12S05-0204GC 5 XPGCHP2 $658.00


Sold individually

Guard ID (mm) Guard Length (mm) Description Part Number Price Quantity
1.0 - 4.0 10 HPLC Guard Cartridge Holder XPGCHP1 $252.00
1.0 - 4.0 20 HPLC Guard Cartridge Holder XPGCHP2 $252.00