Different Separation Characteristics from Bare Silica Gel
YMC-Pack Diol-NP shows typical normal-phase retention behavior when used with low-polarity mobile phases due to hydroxyl groups on the surface of the stationary phase acting as polar groups. Diol-NP is as widely applicable to normal-phase separations as standard silica gel, but is useful in cases where separation optimization is difficult to achieve with silica. In addition, it can also be used in HILIC-mode with organic/water mobile phases.
A Normal-Phase Alternative to Silica
YMC-Pack Diol-NP stationary phase is a versatile alternative to silica for normal-phase separations. The bonded layer’s hydroxyl groups provide good selectivity without excessive retention, since hydrogen bonding with the Diol-NP layer is not as strong as with silanols on a bare silica surface. Diol-NP columns also provide much better reproducibility when compared to bare silica material.
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