This 20 minute seminar (plus Q&A) illustrates scalable models for virus validation studies. In this study, retro‐ (X‐MuLV) and parvo‐virus (MVM) clearance in twin‐column continuous capture chromatography (CaptureSMB) was investigated and a surrogate model was developed using standard batch mode chromatography.
The results showed that the log reduction values (LRVs) achieved during CaptureSMB were also comparable to the LRVs obtained using standard batch capture chromatography and that virus carryover could be well controlled. Further this presentation also shows assessments of the impact of resin cleaning strategy and the duration of clean‐in‐place solution exposure on virus carryover.
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