SFC Columns
YMC delivers 11 different phases for SFC separations giving the chemist good choices for SFC achiral separations.
11 different phases- Analytical or Prep
- Columns with 3, 5, or 10 micron packings
- YMC's hallmark attention to particle and chemistry details
Analytical 4.6 x 25 cm columns packed with 5 um particles are listed below. Please inquire for columns packed with 3 and 10 um packings and preparative version of the below listed columns.
The stationary phases used in YMC SFC columns are specially formulated for SFC use, but are subject to the same rigorous chemical and physical property standards that have been the hallmark of YMC HPLC columns for decades.
SFC can offer some advantages over HPLC for similar applications. The low viscosity of supercritical carbon dioxide allows for analytical separations 3-5 times faster that those for normal phase HPLC. Speed of the SFC separations, conservation of organic solvents, and more concentrated product fractions make SFC a desirable preparative chromatographic technique for purifying chemical mixtures.
All YMC SFC columns are packed specifically for use in SFC, and are tested under SFC conditions.
| Phase | Column Size | Part Number | Description |
| 2-ethyl pyridine | 4.6 x 250 mm | EP06S05-2546PS | 5 micron, 60Å |
| Diol | 4.6 x 250 mm | DP06S05-2546PS | 5 micron, 60Å |
| Diol | 4.6 x 250 mm | DL12S05-2546PS | 5 micron, 120Å |
| diethylaminopropyl | 4.6 x 250 mm | DE06S05-2546PS | 5 micron, 60Å |
| pyridine amide | 4.6 x 250 mm | PY06S05-2546PS | 5 micron, 60Å |
| propyl acetamide | 4.6 x 250 mm | PP06S05-2546PS | 5 micron, 60Å |
| silica | 4.6 x 250 mm | SL12S05-2546PS | 5 micron, 120Å |
| Polyamine II | 4.6 x 250 mm | PB12S05-2546PS | 5 micron, 120Å |
| amino | 4.6 x 250 mm | NH12S05-2546PS | 5 micron, 120Å |
| cyano | 4.6 x 250 mm | CN12S05-2546PS | 5 micron, 120Å |
| PVA-Sil | 4.6 x 250 mm | PV12S05-2546PS | 5 micron, 120Å |
Every application is different. To illustrate the selectivity behavior of the different phases we used a standard mix of common pharmaceutical compounds and separated them under otherwise identical conditions on eight of the columns in the table above.
Separation Conditions:
| Modifier | : | Methanol w/0.1% Diethylamine |
| Gradient Elution | : | 5% modifier - 65% modifier over 12.5 minutes |
| Flow Rate | : | 3.5 mL/min |
| Outlet Pressure | : | 150 bar |
| Column Temp. | : | 40°C |
| Detection | : | 230 nm |
| Injection Volume | : | 5µL |
| Particle size of material | : | 5µm |
| Pore size of material | : | 120Å, except as noted |
| Column Dimensions | : | 250 x 4.6mm |
Analytes:
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