Continuous Chromatography Workshop

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Event Information

J Preston, PhD 
Director of Separation Sciences

Dates: June 11 – 13, 2024
Location: YMC America Insight Center Lab in Devens, MA
Price: $2,500 per person

This valuable training led by J Preston, PhD will include three days of instruction and hands-on experience with a continuous chromatography system, as well as a tour of the YMC America facility.

View the agenda below and select “Register Now” to reserve your seat.

If you need more information, contact your local rep or email sales@ymcpt.com.

 

Agenda

Day 1 Day 2
  • Presentation: Introduction to Continuous Chromatography
  • Lab Workshop: Introduction to small scale systems and batch methodology
  • Presentation: Introduction to technology wizards for fast reproducible results
  • Lab Workshop: Turning batch data into MCSGP methods and interpretation of the data
  • Presentation: Scaling Up Continuous Chromatography
    • Control of Continuous Chromatography
    • Regulatory Aspects
  • Presentation: Evaluation of Continuous Chromatography
    • Performance Metrics
    • Economic Evaluation
    • Introduction to Chromatography Modeling and Simulations
  • Lab Workshop: ChromIQ Evaluation Center
    • Evaluation of Continuous Chromatography Data
  • Presentation: Twin Column Optimization
    • Determination of Throughput and Yield
  • Lab Workshop: Optimization of Loading and Column Regeneration
Day 3
  • Presentation: Using UV-based Dynamic Process Control
    • Introduction to N-Rich® technology
  • Lab Workshop: Optimization of gradients
  • Presentation: Advanced CUBE Techniques
    • Multi-step Gradients
    • Expert Mode Programming
    • Fractionation Tables
  • Presentation: Solvent Usage Minimization
    • MCSGP Troubleshooting

Included with Registration:

    • Presentations by J Preston, PhD
    • Hands-on time in the lab
    • Dinner with Mark Dyment,
      President & CEO of YMC America
    • Tour of YMC America’s facility

Lunch will also be provided each day of the workshop. Please note any dietary restrictions on your registration form.

Register Now

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    Resources

    Below are some resources for those who just can’t wait to start learning!

    N-Rich® Technology

    The N-Rich technique is a twin-column cyclical enrichment process whereby a target molecule or chromatographic region is selectively enriched while the undesired products are simultaneously depleted.

    View this informational page for an overview of N-Rich technology, a visual animation of the process, and some published case studies.

     


    YMC Contichrom® CUBE

    The Contichrom CUBE is a flexible purification system for process development of (bio-)pharmaceuticals such as monoclonal antibodies, peptides, and oligonucleotides. It performs batch, integrated batch, and continuous processes. Workshop attendees will be using this benchtop system during the hands-on segments!
    For more detailed information, view the product page or download our brochure.

       


    Technical Publications

    Poster: Oligo Purification Process Improvements with Twin-Column Chromatography
    View Poster

    Poster: Chiral Prep Chromatography Utilizing Twin-Column Technology
    View Poster

    Journal Article: Enrichment and purification of peptide impurities using twin-column continuous chromatography
    View Article

    Application Note: Purification of a Therapeutic Oligonucleotide Using Twin-Column Chromatography (MCSGP)
    View Application Note