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HILIC Chromatography Products

hilic chromatography productsRest assured, YMC America strives to provide superior products and services for our liquid chromatography customers. When you buy HILIC columns from YMC, you can count on receiving only the highest-quality products for the chromatographic separations that your staff performs in the lab. Please review the details below if you’re thinking about buying a HILIC column from YMC:


  • HILIC is primarily used for the study of extremely polar analytes
  • HILIC eluents are typically compatible with LC-MS systems

HILIC (hydrophilic interaction liquid chromatography) bridges the gap between reversed phase and normal phase chromatography since polar compounds can be retained while using eluents (ie: acetonitrile/water) and buffers that are appropriate for LC-MS.

HILIC works effectively on a number of different stationary phase chemistries, with Diol (dihydroxypropyl group) phases being the most commonly used. Exceptional reproducibility is carried out through the use of the dihydroxypropyl group—a neutral functional group that exhibits low, non-specific adsorption qualities.

There are two Diol phases for HILIC available through YMC:

  • YMC-Triart Diol HILIC
  • YMC-Pack Diol NP

YMC-Triart Diol HILIC

  • Triart Diol-HILIC starts with an organic/inorganic hybrid base particle with exceptional durability and versatility throughout a wide pH range of 2-10.
  • Triart Diol-HILIC is ideal for the analysis of polar and hydrophilic compounds, which are not retained by reversed phase (C18, C8, and others) chromatography.
  • YMC-Triart Diol HILIC columns packed with 1.9 μm particle sizes are suggested for UHPLC, and 3 and 5 μm for conventional HPLC.

HILIC Columns

Here’s an example as to why you should buy a HILIC column from YMC:

Melamine—which people often mistake with the plant and animal compound, melanin—is an industrial chemical used during the manufacturing process of plastic products. However, studies have shown that certain milk companies have used it while processing milk in an attempt to synthetically increase the apparent protein content. These studies have also suggested that melamine contamination of food products could possibly be linked to damage of renal cells that may eventually lead to kidney failure.

In recent years, there has been much emphasis placed on melamine in milk and food products, including chocolate. As a way to prevent accidents caused by melamine contamination, it is crucial to develop analytical methods that can monitor the level of melamine without compromising resolution caused by compounds that elicit background signals from the sample matrix. Since melamine is a polar compound it can be difficult to retain on traditional reversed-phase columns, therefore it is better suited for analysis using HILIC chromatography. Fortunately, when customers buy YMC Triart Diol-HILIC and YMC-Pack Diol NP columns from YMC America, they can trust that they have purchased a robust and rugged HILIC column, which uses eluents that are mass spec-friendly.

Want to learn more about how to buy HILIC columns from YMC America? Click on any of the links leading to the individual product pages or simply contact us to speak with a professional. Customers are also encouraged to stay up to date with the latest information on developments at YMC America by visiting our News page, our Facebook and our LinkedIn.

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